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GlossaryPI3K/AKT pathway

regulates cell growth, survival, and metabolism

The PI3K/AKT pathway is a critical cell signaling pathway that helps regulate various cellular processes, including growth, survival, and metabolism. When activated, it can promote cell proliferation and inhibit programmed cell death (apoptosis), making it significant in contexts like cancer research and treatment, as well as in understanding hair growth and conditions like alopecia.

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research PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration

30 citations, April 2020 in “Stem Cell Research & Therapy”

PI3K/Akt pathway is crucial for hair growth and regeneration.

research Exercise Activates the PI3K-AKT Signal Pathway by Decreasing the Expression of 5α-Reductase Type 1 in PCOS Rats

28 citations, May 2018 in “Scientific reports”

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

research Effects of the PI3K/Akt Signaling Pathway on the Hair Inductivity of Human Dermal Papilla Cells in Hair Beads

12 citations, April 2022 in “Journal of Bioscience and Bioengineering”

Activating the PI3K/Akt pathway improves hair growth by human dermal papilla cells in hair beads.

research LncRNA RP11-818024.3 Promotes Hair-Follicle Recovery Via FGF2-PI3K/Akt Signal Pathway

January 2022 in “SSRN Electronic Journal”

LncRNA RP11-818024.3 helps hair growth and recovery in hair loss by boosting cell survival and reducing cell death.

research Caizhixuan Hair Tonic Regulates Both Apoptosis and the PI3K/Akt Pathway to Treat Androgenetic Alopecia

February 2023 in “PLOS ONE”

Caizhixuan hair tonic helps treat hair loss by promoting hair growth and improving hair follicles.

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community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 122 upvotes 7 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Does melatonin dissolve in isopropyl alcohol

in Technology 7 upvotes 1 year ago

The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 668 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.