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GlossaryAKT1

gene involved in cell growth and survival

AKT1 is a gene that produces a protein involved in cell growth, survival, and metabolism. In simpler terms, it's like a switch that helps cells grow and stay alive. For professionals, AKT1 is a serine/threonine kinase that plays a critical role in the PI3K/AKT signaling pathway, which is often implicated in cancer and other diseases due to its role in promoting cell proliferation and inhibiting apoptosis.

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research Expression of AKT1 Along with AKT2 in Granulosa-Lutein Cells of Hyperandrogenic PCOS Patients

24 citations, March 2017 in “Archives of Gynecology and Obstetrics”

The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.

research Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities

36 citations, January 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

research Protein Kinase Akt2/PKBβ Is Involved in Blastomere Proliferation of Preimplantation Mouse Embryos

7 citations, September 2019 in “Journal of Cellular Physiology”

Akt2 protein is essential for normal cell division in early mouse embryos.

research Elucidating the Anti-Aging Mechanism of Si Jun Zi Tang by Integrating Network Pharmacology and Experimental Validation In Vivo

6 citations, May 2022 in “Aging”

Si Jun Zi Tang may slow aging by affecting specific cell signaling pathways.

Logic-Based Modeling and Drug Repurposing for the Prediction of Novel Therapeutic Targets and Combination Regimens Against E2F1-Driven Melanoma Progression

research Logic-Based Modeling and Drug Repurposing for the Prediction of Novel Therapeutic Targets and Combination Regimens Against E2F1-Driven Melanoma Progression

1 citations, November 2023 in “BMC chemistry”

Tadalafil and Finasteride may help treat aggressive melanoma.

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