Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche

    June 2013 in “ The Journal of Pathology ”
    Matthew Harries, Katja C. Meyer, Iskander H. Chaudhry … Ralf Paus
    Studysummary This study found that immune privilege collapse in the hair follicle bulge and associated immune responses may contribute significantly to the pathogenesis of lichen planopilaris, suggesting a potential autoimmune basis for the disease.
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    Research cited in this study 25

    1. Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    2. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    3. Treatment Options for Alopecia: An Update, Looking to the Future Expert Opinion on Pharmacotherapy · 2012
    4. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    5. Cicatricial (Scarring) Alopecias: Comprehensive Review and Management American Journal of Clinical Dermatology · 2012
    6. Dissecting the Bulge in Hair Regeneration Journal of Clinical Investigation · 2012
    7. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    8. Primary Cicatricial Alopecia: Recent Advances in Understanding and Management The Journal of Dermatology · 2011
    9. Can the Hair Follicle Become a Model for Studying Selected Aspects of Human Ocular Immune Privilege? Investigative Ophthalmology & Visual Science · 2011
    10. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    11. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    12. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010
    13. Lichen Planopilaris Treated With a Peroxisome Proliferator-Activated Receptor Gamma Agonist Archives of dermatology · 2009
    14. Does Collapse of Immune Privilege in the Hair-Follicle Bulge Play a Role in the Pathogenesis of Primary Cicatricial Alopecia? Clinical and Experimental Dermatology · 2009
    15. Nonviral In Situ Green Fluorescent Protein Labeling and Culture of Primary, Adult Human Hair Follicle Epithelial Progenitor Cells Stem Cells · 2009
    16. Lichen Planopilaris: Update on Diagnosis and Treatment Seminars in Cutaneous Medicine and Surgery · 2009
    17. Management of Primary Cicatricial Alopecias: Options for Treatment British Journal of Dermatology · 2008
    18. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    19. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    20. Frontal Fibrosing Alopecia Versus Lichen Planopilaris: A Clinicopathological Study International Journal of Dermatology · 2006
    21. Gene Expression Profiling Gets to the Root of Human Hair Follicle Stem Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    22. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    23. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    24. Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia Journal of Investigative Dermatology · 2004
    25. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001

    Related research 5

    1. Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    2. Feature Characterization of Scarring and Non-Scarring Types of Alopecia by Multiphoton Microscopy Lasers in Surgery and Medicine · 2018
    3. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018
    4. The Immunopathobiology of Lichen Planopilaris [Thesis]. Manchester, UK: The University of Manchester; 2011. · 2011
    5. Does Collapse of Immune Privilege in the Hair-Follicle Bulge Play a Role in the Pathogenesis of Primary Cicatricial Alopecia? Clinical and Experimental Dermatology · 2009