Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia
primary cicatricial alopecia PCA scarring alopecia CD8+ T cells epithelial hair follicle stem cells eHFSCs adoptive transfers OT1 T cells autoimmune-prone mice ovalbumin keratin 5 promoter skin fibrosis CD200R immunoregulatory hair follicles gene expression lichen planopilaris LPP central centrifugal cicatricial alopecia CCCA discoid lupus erythematosus DLE hair follicle stem cells autoimmune mice skin scarring immune regulation hair follicle protection gene similarities
Studysummary This study reports that CD200R expression is significantly reduced in an experimental mouse model of scarring alopecia, suggesting a potential role for this pathway in immune regulation and hair follicle protection.
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