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the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil
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an anticonvulsant repurposed for hair loss via histone inhibition
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Research
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research Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia
The study found that a key immune pathway protecting hair follicles is reduced in a mouse model of scarring hair loss.
research Investigating the roles of cellular senescence in embryogenesis and aging
The study explored the dual roles of cellular senescence in aging and embryonic development. In aging, particularly within the epidermal stem cell population, an increase in Keratin-15 positive hair follicle stem cells was observed, but these cells showed reduced functionality and stress tolerance, linked to an imbalance in Jak-Stat signaling rather than direct senescence. This suggested that extrinsic senescence contributes to tissue aging. Conversely, during embryogenesis, senescence was identified as a normal mechanism, crucial for processes like apical ectodermal ridge maintenance, and was dependent on p21. Mice lacking p21 showed defects in embryonic development. The study also found gene-expression similarities between developmental and oncogene-induced senescence, indicating a shared function. Senescence in development involved apoptosis and immune clearance, suggesting it originally evolved as a developmental mechanism before being adapted for adult roles.
research Novel Small-Insertion Mutation in the LIPH Gene in a Patient with Autosomal Recessive Woolly Hair/Hypotrichosis
Researchers found a new mutation in the LIPH gene of a woman with a rare hair condition.
research Genome-Wide DNA Methylation and Transcriptome Analyses Reveal the Key Gene for Wool Type Variation in Sheep
The SOSTDC1 gene is crucial for determining sheep wool type.
research The Pioneer Factor SOX9 Competes for Epigenetic Factors to Switch Stem Cell Fates
SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.
Community Join
5 / 377 resultscommunity 3 months progress!! Fin + Min + Derma roller + Nizoral Shampoo.
The post discusses a user's successful hair regrowth after 3 months using 1 mg oral finasteride, oral minoxidil, weekly 1.5mm derma rolling, and Nizoral shampoo every other day, with no side effects. The conversation includes various responses, questions about the user's ethnicity and previous scalp condition, and suggestions for topical treatments.
community Being Safe on Oral Minoxidil: tl;dr on the literature.
Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.
community The Real Cause Of Androgenetic Alopecia
Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.
community Why is nobody studying the difference between donor and balding hair?
The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.
community Reminder how little the average person knows about hair loss
How little the average person knows about hair loss and how it can be an unfairly stigmatized issue, even by people with little knowledge of it themselves. Some specific treatments that were discussed include finasteride, RU58841, dutasteride, minoxidil, pyritinol, dermarolling, and diet/lifestyle changes.