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Glossary Gene Transcription

process where DNA is converted into RNA

Gene transcription, also known simply as transcription, is the process by which a cell converts a segment of DNA into RNA. This is a crucial step in gene expression, where the information encoded in a gene is used to produce a functional product, typically a protein. During transcription, an enzyme called RNA polymerase reads the DNA sequence of a gene and synthesizes a complementary RNA strand, which can then be translated into a protein or serve other functions within the cell.

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Research

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research Skin transcriptomic and selection signature analyses identify ASIP as a key gene in cattle coat color determination

2 citations , April 2025 in “Frontiers in Genetics”

This study investigated the genetic basis of coat color variation in cattle using skin transcriptome and whole-genome analyses, identifying the ASIP gene as a significant determinant that is differentially expressed and under strong positive selection in black and brown cattle breeds.

research Combination of Transcriptomics and Proteomics Reveals Differentially Expressed Genes and Proteins in the Skin of EDAR Gene-Targeted and Wildtype Cashmere Goats

1 citations , April 2023 in “Animals”

This study utilized EDAR gene-targeted cashmere goats to identify 732 differentially expressed genes and 140 proteins associated with abnormal hair growth, providing insights into the regulatory mechanisms of cashmere follicle development.

research Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease

1 citations , February 2016 in “Cell Transplantation”

In this study, researchers found that hair follicles and dermal fibroblasts, including dermal papilla cells, supported sustained hair growth in transplanted murine models, with RNA-seq analysis revealing active signaling pathways and gene expression patterns.

research Differential gene expression analysis between anagen and telogen of Capra hircus skin based on the de novo assembled transcriptome sequence

31 citations , March 2013 in “Gene”

This study sequenced and analyzed the goat skin transcriptome, revealing genes involved in signal transduction and cell communication that are differentially expressed during hair growth phases, providing insights for Cashmere goat breeding.

research Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis

7 citations , August 2020 in “Genes”

This study mapped gene expression in different skin structures of dogs, finding similarities to humans that support using dogs as models for human skin diseases.

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community Minoxidil is a 5ar inhibitor according to research

150 upvotes 11 months ago

Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

community Desensitize Follicle Sensitivity to DHT?

12 upvotes 1 month ago

Hair follicles cannot be desensitized to DHT like allergies; treatments focus on reducing DHT levels or blocking its effects using methods like finasteride, GT20029, or PROTACs. Topical treatments like ceterizine and BPA application are also mentioned.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

112 upvotes 2 years ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community What's your option on complementary treatment

3 upvotes 2 years ago

The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.

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Clinics

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Hair Loss Treatments
Gene Lee Skin ClinicSan Diego, CA · US

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