ELL Facilitates RNA Polymerase II-Mediated Transcription of Human Epidermal Proliferation Genes

    May 2021 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Jingting Li, Varun Bansal, Manisha Tiwari, Yifang Chen, George L. Sen
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    TLDR ELL is crucial for gene transcription related to skin cell growth.
    The document from May 1, 2021, detailed a study on the role of ELL, a protein in the super elongation complex, in the transcription of genes that regulate epidermal cell proliferation. The study showed that ELL is essential for the stabilization of RNA Polymerase II at the transcription start sites of these genes, which is crucial for maintaining their expression. Knockdown of ELL in human keratinocytes resulted in decreased cell numbers due to apoptosis and a reduction in the proliferative marker Ki67. RNA sequencing indicated that 661 genes were downregulated, mainly those involved in DNA replication and cell cycle, while 1,280 genes were upregulated, related to extracellular matrix organization and cell migration. The findings suggest that ELL is not only important for transcription elongation but also for Pol II stabilization at the TSS, which is vital for the transcription of proliferation genes in the epidermis. The study's data are available in the Gene Expression Omnibus database, and the research was supported by the National Institutes of Health.
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