Impaired Skin And Hair Follicle Development In Runx2 Deficient Mice
January 2008
in “
Developmental Biology
”
Research cited in this study
19 / 19 resultsresearch Dynamic Expression of Runx1 in Skin Affects Hair Structure
Runx1 is crucial for proper hair structure and development.
research Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression
This study found that loss of Ptch1 function in mouse skin's basal cells is sufficient to rapidly induce tumors resembling human basal cell carcinoma, suggesting Ptch1 as a key tumor suppressor.
research Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway
This study found that a topical hedgehog agonist can stimulate hair growth by promoting the transition from the resting to growth phase of the hair cycle in adult mouse skin.
research Runx3 Is Involved in Hair Shape Determination
This study found that Runx3 deficiency in mice affects hair type and shape, suggesting it may regulate hair formation through interactions between dermal and epidermal layers.
research Overexpression Of Sonic Hedgehog Suppresses Embryonic Hair Follicle Morphogenesis
This study in mice found that overexpressing Sonic Hedgehog in basal cells caused skin anomalies and a lack of certain hair fibers, underscoring its key role in hair follicle development.
research Molecular Mechanisms Regulating Hair Follicle Development
This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.
research Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration
This study demonstrated that blocking the Sonic hedgehog signaling pathway in mice led to reversible inhibition of body coat hair morphogenesis, while whisker development was unaffected.
research Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog
This study found that administering an adenovirus vector to increase Sonic hedgehog gene expression in mouse skin accelerated the transition of hair follicles into the growth phase, promoting hair growth.
research The Biology of Hair Follicles
This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.
research The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation
This study found that the loss of a functional hr gene in mice leads to premature and abnormal hair follicle regression, disrupting normal hair cycling and architecture.
research Disorders of Hair Growth: Diagnosis and Treatment
This review discusses comprehensive information on hair growth, its clinical and environmental influences, and provides a detailed guide for diagnosing hair loss, but reports no new clinical results.
research Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle
This study found that the switch-off of melanogenesis during the hair cycle in C57 BL-6 mice is a gradual and stochastic process starting in mid anagen VI, with specific biochemical markers indicating the transition to catagen.
research Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools
This collection reviews various animal models for dermatological research, particularly focusing on genetic mutations in laboratory mice, and reports no original findings.
research Disorders of Hair Growth: Diagnosis and Treatment
This review discusses various aspects of hair biology and pathology, including hair growth control, hair loss causes, and scalp conditions, and reports no clinical results.
research Hair Follicle Stem Cells: Their Location, Role in Hair Cycle, and Involvement in Skin Tumor Formation
research The Secret Life of the Hair Follicle
This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.
research Epithelial Growth by Rat Vibrissae Follicles In Vitro Requires Mesenchymal Contact via Native Extracellular Matrix
Epithelial cell growth in rat hair follicles needs contact with mesenchymal cells through the extracellular matrix.
research Growth of the Hair
Hair growth is cyclic and influenced mainly by local factors.
research Critical Stages of Hair Development and Pigmentation in the Mouse
Hair growth and pigmentation in mice involve specific stages crucial for research.