Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression

    February 2006 in “ Cancer Research ”
    Christelle Adolphe, Rehan Hetherington, Tammy Ellis, Brandon J. Wainwright
    Studysummary This study found that loss of Ptch1 function in mouse skin's basal cells is sufficient to rapidly induce tumors resembling human basal cell carcinoma, suggesting Ptch1 as a key tumor suppressor.
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    Research cited in this study 7

    1. An In Vivo Comparative Study of Sonic, Desert, and Indian Hedgehog Reveals That Hedgehog Pathway Activity Regulates Epidermal Stem Cell Homeostasis Development · 2004
    2. Krt6a-Cre Transgenic Mice Direct LoxP-Mediated Recombination to the Companion Cell Layer of the Hair Follicle and Following Induction by Retinoic Acid to the Interfollicular Epidermis Journal of Investigative Dermatology · 2004
    3. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    4. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    5. The Mouse Keratin 6 Isoforms Are Differentially Expressed in the Hair Follicle, Footpad, Tongue, and Activated Epidermis Differentiation · 1999
    6. A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    7. Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors Nature · 1997