An In Vivo Comparative Study of Sonic, Desert, and Indian Hedgehog Reveals That Hedgehog Pathway Activity Regulates Epidermal Stem Cell Homeostasis

    September 2004 in “ Development ”
    Christelle Adolphe, Monica Narang, Tammy Ellis … Brandon J. Wainwright
    Studysummary This study suggests that deregulation of sonic and desert hedgehog signaling in mouse skin can lead to altered epidermal stem cell activity and lesions similar to human basal cell carcinoma, indicating these cancers may originate outside the stem cell population.
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    Research cited in this study 3

    1. Overexpression Of Sonic Hedgehog Suppresses Embryonic Hair Follicle Morphogenesis Developmental Biology · 2003
    2. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    3. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999

    Related research 1

    1. Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors Nature · 1997