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    Glossary Desert Hedgehog

    gene involved in hair follicle development and cell differentiation

    Desert Hedgehog (DHH) is a gene that encodes a signaling protein involved in the development of various tissues, including hair follicles. It plays a crucial role in the regulation of cell growth and differentiation, particularly in the formation of the dermal papilla, which is essential for hair follicle development and cycling. Mutations or disruptions in the DHH gene can lead to hair growth disorders and contribute to conditions like alopecia.

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    Research 10 of 270

    1. An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis Development · 2004 · 99 citations
    2. The effects of sonic, desert and Indian hedgehog signalling in skin 2003
    3. Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2005 · 113 citations
    4. Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies American Journal of Clinical Dermatology · 2024 · 10 citations
    5. Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation FEBS Journal · 2021 · 23 citations
    6. Abstract CN06-04: The hedgehog signaling pathway in cancer. Molecular Cancer Therapeutics · 2011
    7. Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology International journal of dermatology and venereology · 2019
    8. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011 · 396 citations
    9. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020 · 77 citations
    10. Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms ˜The œAmerican journal of pathology · 2011 · 68 citations
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