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Glossary Desert Hedgehog

gene involved in hair follicle development and cell differentiation

Desert Hedgehog (DHH) is a gene that encodes a signaling protein involved in the development of various tissues, including hair follicles. It plays a crucial role in the regulation of cell growth and differentiation, particularly in the formation of the dermal papilla, which is essential for hair follicle development and cycling. Mutations or disruptions in the DHH gene can lead to hair growth disorders and contribute to conditions like alopecia.

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Research

5 / 342 results

research An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis

99 citations , September 2004 in “Development”

This study suggests that deregulation of sonic and desert hedgehog signaling in mouse skin can lead to altered epidermal stem cell activity and lesions similar to human basal cell carcinoma, indicating these cancers may originate outside the stem cell population.

research The effects of sonic, desert and Indian hedgehog signalling in skin

January 2003

This study found that Shh and Dhh overexpression in mouse basal cells led to similar epidermal and limb phenotypes, suggesting Dhh functions similarly to Shh in skin, unlike Ihh.

research Hedgehog and Gli Signaling in Embryonic Mammary Gland Development

25 citations , May 2013 in “Journal of mammary gland biology and neoplasia”

This review examines the roles of Hedgehog and Gli proteins in mouse embryonic mammary development and suggests that Gli3-repressor-mediated off-state of Hedgehog signaling determines mammary fate over hair follicle fate.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations , May 2011 in “Cell stem cell”

This study found that Shh from neurons signals to Gli1-expressing cells in the hair follicle, cultivating a niche where these bulge cells can potentially transform into epidermal stem cells in wound healing.

research From basal cell carcinoma morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots

17 citations , June 2017 in “British Journal of Dermatology”

This review examines the interaction between hedgehog and Wnt/β-catenin signalling in hair follicles and basal cell carcinoma, linking Hh pathway inhibition to both tumor regression and alopecia.

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