Search

for
Search:

Glossary Hedgehog Proteins

regulate tissue growth and development through signaling pathways

Hedgehog Proteins (Hh Proteins) are a group of signaling molecules that play a crucial role in regulating the growth and development of various tissues and organs in the body. They are essential for processes such as cell differentiation, tissue patterning, and the maintenance of stem cells. In the context of hair biology, Hedgehog signaling is important for hair follicle development and cycling, and disruptions in this pathway can contribute to conditions like alopecia.

Related Terms

Research

5 / 1000+ results

research Hair growth-promoting effect of recombinant human sonic hedgehog proteins

3 citations , December 2019 in “Biomedical dermatology”

This study reported that recombinant sonic hedgehog proteins can promote hair growth by activating hair-related genes and signaling pathways, suggesting potential as a therapeutic agent in mice.

Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

research Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

14 citations , June 2018 in “Frontiers in pharmacology”

In this study, EGCG from green tea promoted mink hair follicle growth and cell proliferation at specific concentrations, potentially through activation of Shh and AKT signaling pathways.

research LncRNA-XIST promotes dermal papilla induced hair follicle regeneration by targeting miR-424 to activate hedgehog signaling

11 citations , March 2020 in “Cellular Signalling”

In this study, knockdown of XIST in 3D-cultured dermal papilla cells inhibited hair follicle regeneration by interfering with miR-424 and hedgehog signaling, highlighting XIST's role in hair development.

research Hedgehog and Gli Signaling in Embryonic Mammary Gland Development

25 citations , May 2013 in “Journal of mammary gland biology and neoplasia”

This review examines the roles of Hedgehog and Gli proteins in mouse embryonic mammary development and suggests that Gli3-repressor-mediated off-state of Hedgehog signaling determines mammary fate over hair follicle fate.

research Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

70 citations , August 2006 in “Cancer Research”

This study found that inhibiting AP-1 activity in mice modified tumor development, leading to transdifferentiation between squamous and sebaceous tumors, with molecular analysis suggesting AP-1's role in maintaining tumor cell identity.

View more "hedgehog proteins" in research →

Community Join

5 / 12 results

community New study suggests hair regrowth on wounded and bald skin may be possible

4 upvotes 7 years ago

Hair regrowth on wounded and bald skin may be possible by activating the sonic hedgehog gene, leading to hair regrowth in mice. The findings are promising but may not directly apply to humans.

community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

14 upvotes 3 years ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

community Most Promising Future Hair Loss Treatments In 2026

83 upvotes 4 days ago

Promising hair loss treatments in 2026 include GT20029, a topical androgen receptor degrader, and VDPHL01, an extended-release oral minoxidil, both offering safer alternatives with fewer side effects. Other treatments like sublingual minoxidil, OND-1, JW0061, TDM-105795, and AMP-303 are also being explored.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 7 upvotes 2 years ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

View more "hedgehog proteins" in community →

Learn

2 / 801 results

learn SCUBE3

How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.

learn Lupine protein

View more "hedgehog proteins" in learn →

Experts

— no results

Try a deeper search in experts →

Clinics

— no results

Try a deeper search in clinics →