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    Glossary Hedgehog Proteins

    regulate tissue growth and development through signaling pathways

    Hedgehog Proteins (Hh Proteins) are a group of signaling molecules that play a crucial role in regulating the growth and development of various tissues and organs in the body. They are essential for processes such as cell differentiation, tissue patterning, and the maintenance of stem cells. In the context of hair biology, Hedgehog signaling is important for hair follicle development and cycling, and disruptions in this pathway can contribute to conditions like alopecia.

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    1. Hair growth-promoting effect of recombinant human sonic hedgehog proteins Biomedical dermatology · 2019 · 3 citations
    2. Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways Frontiers in pharmacology · 2018 · 14 citations
    3. Hedgehog and Gli Signaling in Embryonic Mammary Gland Development Journal of mammary gland biology and neoplasia · 2013 · 25 citations
    4. Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity Cancer Research · 2006 · 70 citations
    5. Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state Developmental cell · 2022 · 25 citations
    6. LncRNA-XIST promotes dermal papilla induced hair follicle regeneration by targeting miR-424 to activate hedgehog signaling Cellular Signalling · 2020 · 11 citations
    7. Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity 2023
    8. Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity 2023
    9. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    10. Single-cell analysis of basal cell carcinoma reveals heat shock proteins promote tumor growth in response to WNT5A-mediated inflammatory signals bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 1 citations
    11. Aminoacyl tRNA synthetase complex interacting multifunctional protein 1 induces proliferation of CD34+ hair follicle stem cell Seoul National University Open Repository (Seoul National University) · 2017
    12. Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (<i>Atelerix albiventris</i>) bioRxiv (Cold Spring Harbor Laboratory) · 2020
    13. Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris) Scientific reports · 2020 · 2 citations
    14. GPCRs as key regulators in wound healing Frontiers in Cell and Developmental Biology · 2026
    15. Hair growth-promoting activity of hot water extract of Thuja orientalis BMC Complementary and Alternative Medicine · 2013 · 54 citations
    16. Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair Developmental Cell · 2013 · 52 citations
    17. Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis Frontiers in genetics · 2019 · 6 citations
    18. Molecular Signaling and Nutritional Regulation in the Context of Poultry Feather Growth and Regeneration Frontiers in Physiology · 2020 · 4 citations
    19. Regulation of stem cell fate by HSPGs: implication in hair follicle cycling npj Regenerative Medicine · 2022 · 3 citations
    20. Targeting of Skin Antigen-Presenting Cells Journal of Animal Science · 2010
    21. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations 2011 · 41 citations
    22. The Organizer and Beyond Cell · 2001 · 9 citations
    23. Signaling pathways involved in hair follicle cycling and morphogenesis International Journal of Dermatology and Venereology · 2012
    24. Splitting Hairs Cell · 1998 · 158 citations
    25. Deficiency of Formyl Peptide Receptor 2 Retards Hair Regeneration by Modulating the Activation of Hair Follicle Stem Cells and Dermal Papilla Cells in Mice Development & Reproduction · 2021 · 1 citations
    26. Hairy tale of signaling in hair follicle development and cycling Seminars in cell & developmental biology · 2012 · 161 citations
    27. Molecular Mechanisms Regulating Hair Follicle Development 2002 · 854 citations
    28. Scratching the surface of skin development Nature · 2007 · 788 citations
    29. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014 · 223 citations
    30. Molecular biology of hair morphogenesis: Development and cycling Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution · 2003 · 155 citations