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    Glossary GLI Transcription Factors

    proteins regulating gene expression in development and differentiation

    GLI Transcription Factors are proteins that play a crucial role in regulating gene expression during development and cell differentiation. They are part of the Hedgehog signaling pathway, which is essential for proper embryonic development and has been implicated in various cancers when dysregulated.

    Research 10 of 326

    1. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000 · 333 citations
    2. Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems Queen Mary Research Online (Queen Mary University of London) · 2007
    3. Distinct tooth regeneration systems deploy a conserved battery of genes bioRxiv (Cold Spring Harbor Laboratory) · 2020
    4. AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma Nature Communications · 2020 · 60 citations
    5. Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans American Journal Of Pathology · 2006 · 35 citations
    6. Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-β1/β2, and p63 in Sebaceous and Follicular Tumors Annals of Dermatology · 2014 · 8 citations
    7. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    8. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours Nature · 1997 · 638 citations
    9. Epithelial stem cells and implications for wound repair Seminars in Cell & Developmental Biology · 2012 · 156 citations
    10. Function of KLF4 in Stem Cell Biology InTech eBooks · 2013 · 5 citations
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