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    Glossary GLI Transcription Factors

    proteins regulating gene expression in development and differentiation

    GLI Transcription Factors are proteins that play a crucial role in regulating gene expression during development and cell differentiation. They are part of the Hedgehog signaling pathway, which is essential for proper embryonic development and has been implicated in various cancers when dysregulated.

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    1. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000 · 333 citations
    2. Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems Queen Mary Research Online (Queen Mary University of London) · 2007
    3. Distinct tooth regeneration systems deploy a conserved battery of genes bioRxiv (Cold Spring Harbor Laboratory) · 2020
    4. AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma Nature Communications · 2020 · 60 citations
    5. Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans American Journal Of Pathology · 2006 · 35 citations
    6. Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-β1/β2, and p63 in Sebaceous and Follicular Tumors Annals of Dermatology · 2014 · 8 citations
    7. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    8. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours Nature · 1997 · 638 citations
    9. Epithelial stem cells and implications for wound repair Seminars in Cell & Developmental Biology · 2012 · 156 citations
    10. Function of KLF4 in Stem Cell Biology InTech eBooks · 2013 · 5 citations
    11. Recombinant Type XVII Collagen Promotes Hair Growth by Activating the Wnt/β-Catenin and SHH/GLI Signaling Pathways Cosmetics · 2025
    12. ATP-dependent chromatin remodeling during mammalian development Development · 2016 · 182 citations
    13. p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis Journal of Investigative Dermatology · 2015 · 19 citations
    14. Beyond acne: Current aspects of sebaceous gland biology and function Reviews in Endocrine and Metabolic Disorders · 2016 · 97 citations
    15. GLI2 Is Expressed in Normal Human Epidermis and BCC and Induces GLI1 Expression by Binding to its Promoter Journal of Investigative Dermatology · 2004 · 171 citations
    16. A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms International journal of molecular sciences · 2023 · 3 citations
    17. SOX9 in organogenesis: shared and unique transcriptional functions Cellular and Molecular Life Sciences · 2022 · 10 citations
    18. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    19. YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate International Journal of Molecular Sciences · 2024 · 14 citations
    20. Editor's evaluation: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis 2022
    21. SOX2 in the Skin Elsevier eBooks · 2015 · 1 citations
    22. Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects against Malignant Progression Cell Reports · 2013 · 15 citations
    23. Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin Aging Cell · 2009 · 62 citations
    24. Role of vitamin D and calcium signaling in epidermal wound healing Journal of endocrinological investigation · 2022 · 15 citations
    25. Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials Experimental Dermatology · 2018 · 41 citations
    26. Developmentally regulated expression of integrin alpha-6 distinguishes neural crest derivatives in the skin Frontiers in Cell and Developmental Biology · 2023 · 5 citations
    27. Skin Deep and Deeper: Multiple Pathways in Basal Cell Carcinogenesis Cancer Prevention Research · 2010 · 5 citations
    28. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006 · 224 citations
    29. Acne Harper's Textbook of Pediatric Dermatology · 2011 · 2 citations
    30. Scratching the surface of skin development Nature · 2007 · 788 citations