Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects Against Malignant Progression

    July 2013 in “ Cell Reports ”
    Parisa Kakanj, Karen L. Reuter, Gilles Séquaris … Catherin Niemann
    Studysummary This study reported that Indian hedgehog (Ihh) signaling plays a crucial role in regulating tumor progression and metastasis in epithelial cancers, with Ihh deficiency leading to increased malignancy and metastasis in mice.
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    Research cited in this study 11

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    3. TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function Journal of Investigative Dermatology · 2011
    4. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    5. Expression of the Orphan Protein Plet-1 During Trichilemmal Differentiation of Anagen Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    6. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    7. The Cell-Surface Marker MTS24 Identifies a Novel Population of Follicular Keratinocytes With Characteristics of Progenitor Cells Development · 2006
    8. Loss of Keratin 10 Is Accompanied by Increased Sebocyte Proliferation and Differentiation European journal of cell biology · 2004
    9. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    10. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002
    11. Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration Journal of Investigative Dermatology · 2000