TLDR Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.
The document from July 2013 presents findings from a study on the role of Indian Hedgehog (Ihh) in skin tumorigenesis. It was discovered that the absence of Ihh in mouse models led to an increase in benign squamous papilloma formation, a higher incidence of malignant squamous cell carcinoma, and the development of metastases in the lung and lymph nodes. In sebaceous gland tumors, Ihh deficiency resulted in inhibited tumor cell differentiation. Ihh was found to stimulate cell proliferation by activating the transcription factor GLI2 in human keratinocytes and tumors. The study suggests that Ihh signaling is critical for controlling cell proliferation, differentiation, and preventing tumor malignancy. The number of mice used in the experiments varied, with specific numbers provided for different experiments, such as 19 IhhEKO mice and 17 control mice in sebaceous tumor studies, and 20 IhhEKO mice and 19 control mice for squamous papillomas and SCCs studies.
52 citations,
April 2013 in “Developmental Cell” Brg1 is crucial for hair growth and skin repair by maintaining stem cells and promoting regeneration.
138 citations,
June 2012 in “Genes & Development” Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.
22 citations,
September 2011 in “Journal of Investigative Dermatology” TCF/Lef1 is essential for skin barrier function by regulating lipid metabolism.
396 citations,
May 2011 in “Cell stem cell” Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.
30 citations,
February 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Plet-1 protein helps hair follicle cells move and stick to tissues.
36 citations,
January 2004 in “European journal of cell biology” Without keratin 10, there's more growth and development of oil-producing skin cells.
194 citations,
May 2000 in “Journal of Investigative Dermatology” The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.
Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.
Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.
16 citations,
July 2012 in “Current pharmaceutical biotechnology” New treatments for skin conditions related to the sebaceous gland are being developed based on current research.
8 citations,
January 2014 in “Annals of Dermatology” The research suggests that p63 and TGF-β1 may help determine tumor type and malignancy in hair follicle and sebaceous tumors.
97 citations,
September 2016 in “Reviews in Endocrine and Metabolic Disorders” The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.
