Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

Michael J. Gerdes, Maxim Myakishev, Nicholas A. Frost, Vikas Rishi, Jaideep Moitra, Abu-Amer Acharya, Michelle R. Levy, Sang‐Won Park, Adam B. Glick, Stuart H. Yuspa, Charles Vinson

activator protein-1 AP-1 A-FOS alopecia sebaceous gland hyperplasia H-ras mutations wnt/β-catenin pathway hedgehog pathway hair loss sebaceous gland enlargement wnt pathway

Studysummary This study found that inhibiting AP-1 activity in mice can induce lineage transdifferentiation between squamous and sebaceous tumors, suggesting AP-1's role in maintaining tumor cell identity.

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research Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter

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