Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

    March 2023
    Michael J. Gerdes, Maxim Myakishev, Nicholas A. Frost … Charles Vinson
    Studysummary This study found that inhibiting AP-1 activity in mice can induce lineage transdifferentiation between squamous and sebaceous tumors, suggesting AP-1's role in maintaining tumor cell identity.
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    Research cited in this study 2

    1. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000
    2. Ornithine Decarboxylase Expression in Cutaneous Papillomas in SENCAR Mice Is Associated with Altered Expression of Keratins 1 and 10 PubMed · 1994