New Pharmaceutical Concepts for Sebaceous Gland Diseases: Implementing Today's Pre-Clinical Data into Tomorrow's Daily Clinical Practice

July 2012 in “ Current pharmaceutical biotechnology ”

Vasiliki Zampeli, Evgenia Makrantonaki, Thrasivoulos Tzellos, Christos C. Zouboulis

sebaceous gland acne sebum production sebum lipid quality inflammatory processes hormonal imbalances intrinsic aging extrinsic aging androgens UV exposure skin xerosis sebaceous hyperplasia sebaceous carcinoma molecular pathways skin dryness sun exposure

TLDR New treatments for skin conditions related to the sebaceous gland are being developed based on current research.

The document from July 2012 reviews the role of the human sebaceous gland in various skin conditions and the potential for new pharmaceutical treatments targeting these conditions. It highlights that the sebaceous gland is involved in common disorders like acne, which is prevalent in adolescence and young adulthood, and is influenced by factors such as increased sebum production, altered sebum lipid quality, inflammatory processes, and hormonal imbalances. The review also discusses the impact of both intrinsic and extrinsic aging on the sebaceous gland, with intrinsic aging being driven by genetics and hormones, particularly androgens, and extrinsic aging primarily caused by UV exposure, leading to conditions like skin xerosis, sebaceous hyperplasia, and sebaceous carcinoma. The document emphasizes the importance of understanding the molecular pathways involved in sebaceous gland diseases to develop future pharmaceutical interventions.

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New Pharmaceutical Concepts for Sebaceous Gland Diseases: Implementing Today's Pre-Clinical Data into Tomorrow's Daily Clinical Practice

research New Pharmaceutical Concepts for Sebaceous Gland Diseases: Implementing Today's Pre-Clinical Data into Tomorrow's Daily Clinical Practice

16 citations, July 2012 in “Current pharmaceutical biotechnology”

New treatments for skin conditions related to the sebaceous gland are being developed based on current research.