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GlossaryIntrinsic Aging

natural aging process driven by genetic and biological factors

Intrinsic aging, also known as chronological aging, refers to the natural and inevitable process of aging that occurs over time due to genetic and biological factors. This type of aging affects all organs, including the skin and hair, leading to changes such as thinning hair, reduced skin elasticity, and the appearance of fine lines and wrinkles. Unlike extrinsic aging, which is influenced by external factors like sun exposure and pollution, intrinsic aging is driven by the body's internal biological clock.

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Intrinsic Versus Extrinsic Aging: A Histopathological, Morphometric, and Immunohistochemical Study of Estrogen Receptor β and Androgen Receptor

research Intrinsic Versus Extrinsic Aging: A Histopathological, Morphometric, and Immunohistochemical Study of Estrogen Receptor β and Androgen Receptor

9 citations, January 2016 in “Skin Pharmacology and Physiology”

The study concluded that both estrogen and androgen receptors, which decrease with age, are linked to skin aging and may be hormonally regulated.

research Aging in the Male Face: Intrinsic and Extrinsic Factors

27 citations, May 2016 in “Dermatologic Surgery”

Male faces age with more wrinkles and hair loss, influenced by both body changes and environmental factors.

research Spontaneous Intrinsic Aging in Organ-Cultured Human Skin as a Novel Ex Vivo Assay to Test Anti-Aging Actives

November 2022 in “Journal of Investigative Dermatology”

The document concludes that a new method has been developed to test anti-aging substances on human skin, showing that these substances can reduce skin aging signs.

research The Pathobiology of Skin Aging

122 citations, April 2020 in “American Journal Of Pathology”

Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.

research Aging Skin: A Window to the Body

1 citations, April 2016 in “CRC Press eBooks”

Skin aging reflects overall body aging and can indicate internal health conditions.

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community Tretinoin for some men(not all) can cause non-telogen effluvium hair loss

in Research/Science 2 upvotes 3 weeks ago

Tretinoin can cause non-telogen hair loss in some men by inducing catagen-like changes in hair follicles and through retinoid toxicity, especially when used with minoxidil. Some users report hair loss even when using retinoids on the face, while others experience benefits when combined with treatments like finasteride and minoxidil.

community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results

in Update 415 upvotes 6 months ago

ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.

community Scalp tension and thickness of the galea aponeurotica, inflammation and potential treatment pathways

in Research/Science 3 years ago

Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.

community Who here actually noticed new growth after adding ketoconazole?

in Chat 37 upvotes 5 months ago

Ketoconazole is mainly used for improving scalp health and reducing dandruff, but it is not effective for new hair growth. Some users find it complements treatments like minoxidil and finasteride, but results vary.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 9 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

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