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Glossary Intrinsic Aging

natural aging process driven by genetic and biological factors

Intrinsic aging, also known as chronological aging, refers to the natural and inevitable process of aging that occurs over time due to genetic and biological factors. This type of aging affects all organs, including the skin and hair, leading to changes such as thinning hair, reduced skin elasticity, and the appearance of fine lines and wrinkles. Unlike extrinsic aging, which is influenced by external factors like sun exposure and pollution, intrinsic aging is driven by the body's internal biological clock.

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Intrinsic Versus Extrinsic Aging: A Histopathological, Morphometric, and Immunohistochemical Study of Estrogen Receptor β and Androgen Receptor

research Intrinsic versus Extrinsic Aging: A Histopathological, Morphometric and Immunohistochemical Study of Estrogen Receptor β and Androgen Receptor

9 citations , January 2016 in “Skin Pharmacology and Physiology”

This study observed that estrogen receptor β and androgen receptor expressions in the skin decline with age, more noticeably under sun exposure, suggesting a role in skin aging.

research Quantitative morphometric analysis of intrinsic and extrinsic skin ageing in individuals with Fitzpatrick skin types II–III

4 citations , January 2023 in “Experimental dermatology”

This study suggests that both age and photoexposure may decrease maximum viable epidermis thickness and impact the dermal-epidermal junction in women with Fitzpatrick skin types II-III.

research Aging in the Male Face: Intrinsic and Extrinsic Factors

27 citations , May 2016 in “Dermatologic Surgery”

This review examines how male facial anatomy and behavior contribute to sexual dimorphism in facial aging, pointing to factors that accelerate aging in men but presents no new clinical results.

Spontaneous Intrinsic Aging in Organ-Cultured Human Skin as a Novel Ex Vivo Assay to Test Anti-Aging Actives

research 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives

November 2022 in “Journal of Investigative Dermatology”

This study reported that an ex vivo organ culture system effectively induced aging-related changes in healthy human skin, allowing testing of senolytics like tretinoin, resveratrol, and caffeine.

research Skin connective tissue and ageing

77 citations , July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

This review discusses the impact of menopause-related oestrogen deficiency on skin ageing and suggests that oestrogen use may improve collagen and skin elasticity, but it reports no clinical trial results.

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community Tretinoin for some men(not all) can cause non-telogen effluvium hair loss

in Research/Science 5 upvotes 1 year ago

Tretinoin can cause non-telogen hair loss in some men by inducing catagen-like changes in hair follicles and through retinoid toxicity, especially when used with minoxidil. Some users report hair loss even when using retinoids on the face, while others experience benefits when combined with treatments like finasteride and minoxidil.

community Occipitalis Muscle Tension Theory

13 upvotes 7 months ago

Scalp tension from the occipitalis muscle is theorized to contribute to hair loss, but most believe DHT and genetics are the main causes. Treatments like finasteride and minoxidil are considered more effective than addressing scalp tension.

community My Theory Of Androgenic Alopecia

16 upvotes 10 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community How Veradermics secured a total of $220 million in series B and C financing for oral minoxidil, I will never understand.....

in Chat 38 upvotes 10 months ago

Veradermics' oral minoxidil shows promise for hair regrowth, with some users reporting significant improvements, while Pelage's PP405 results are less convincing and lack transparency. There is skepticism about both treatments' long-term effectiveness and potential side effects.

community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results

in Update 415 upvotes 1 year ago

ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.

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