Context-Dependent Effect of sPLA2-IIA Induced Proliferation on Murine Hair Follicle Stem Cells and Human Epithelial Cancer

    September 2019 in “ EBioMedicine ”
    Gopal Chovatiya, Raghava R. Sunkara, Sayoni Roy … Sanjeev K. Waghmare
    Studysummary This study found that Secretory Phospholipase A2-IIA (sPLA2-IIA) promotes proliferation through JNK/c-Jun signaling, distinctively affecting normal stem cells and cancer cells, suggesting it as a potential target for cancer treatment.
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    Research cited in this study 7

    1. Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response Scientific Reports · 2017
    2. sPLA2-IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation Stem cells · 2016
    3. Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation American Journal Of Pathology · 2011
    4. Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin Journal of Biological Chemistry · 2011
    5. Coexistence of Quiescent and Active Adult Stem Cells in Mammals Science · 2010
    6. Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells Molecular biology of the cell · 2008
    7. Expression of Enhancing Factor/Phospholipase A2 in Skin Results in Abnormal Epidermis and Increased Sensitivity to Chemical Carcinogenesis Oncogene · 2003

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