Context-Dependent Effect of sPLA2-IIA Induced Proliferation on Murine Hair Follicle Stem Cells and Human Epithelial Cancer

October 2019 in “ EBioMedicine ”

Gopal Chovatiya, Raghava R. Sunkara, Sayoni Roy, S. Godbole, Sanjeev K. Waghmare

secretory phospholipase A2 group IIA sPLA2-IIA hair follicle stem cells HFSCs label-retaining cells LRCs JNK/c-Jun signaling pathway oral squamous cell carcinoma OSCC skin squamous cell carcinoma SCC JNK signaling

TLDR sPLA2-IIA increases growth in hair follicle stem cells and cancer cells, suggesting it could be targeted for hair growth and cancer treatment.

The study explored the effects of secretory phospholipase A2 group IIA (sPLA2-IIA) on both murine hair follicle stem cells (HFSCs) and human epithelial cancer cells. It was discovered that sPLA2-IIA promotes rapid proliferation in HFSCs, which leads to a decrease in label-retaining cells (LRCs) essential for stem cell maintenance, and this effect is mediated through the JNK/c-Jun signaling pathway. In contrast, sPLA2-IIA was found to enhance tumor growth in human oral squamous cell carcinoma (OSCC) and skin squamous cell carcinoma (SCC) cell lines by upregulating the same signaling pathway. Knockdown experiments of sPLA2-IIA in these cancer cell lines resulted in a significant reduction in tumor volume and decreased JNK/c-Jun signaling. The study, which included 3 mice per genotype and 19 human OSCC tissue samples, concluded that sPLA2-IIA has a context-dependent effect on cell proliferation, promoting growth in both HFSCs and epithelial tumor cells, and thus presents a potential target for hair growth modulation and cancer therapy.

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