sPLA2-IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation

The study demonstrated that overexpression of secretory phospholipase A2 group IIA (sPLA2-IIA) in the epidermis of transgenic mice led to the depletion of hair follicle stem cells (HFSCs) and induced differentiation through enhanced activation of the JNK/c-Jun signaling pathway. This overexpression resulted in increased proliferation, altered differentiation, and loss of stem cell quiescence, accompanied by changes in histone modification profiles. These findings suggested that sPLA2-IIA disrupts HFSC maintenance and promotes differentiation, contributing to hair follicle dysfunction and hair loss, with potential implications for understanding hair loss and developing hair therapies.