31 citations
,
May 2015 in “Stem Cell Reports” Stem cells and their surrounding environment in hair follicles work closely together, affecting hair growth and having implications for cancer and tissue regeneration.
135 citations
,
December 2013 in “Seminars in Cell & Developmental Biology” Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.
211 citations
,
April 2013 in “Development” More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.
150 citations
,
December 2012 in “EMBO Reports” Stem cell self-renewal is complex and needs more research for full understanding.
161 citations
,
August 2012 in “Seminars in cell & developmental biology” Hair growth and development are controlled by specific signaling pathways.
85 citations
,
July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
191 citations
,
September 2011 in “Cell stem cell” Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.
151 citations
,
August 2011 in “The EMBO Journal” 33 citations
,
August 2009 in “Journal of Investigative Dermatology” 
168 citations
,
August 2009 in “EMBO molecular medicine” Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.
1039 citations
,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
98 citations
,
August 2007 in “PLoS ONE” The study explored how Myc activation influenced epidermal stem cells, leading them to differentiate into sebocytes and interfollicular epidermis, accompanied by significant changes in gene transcription. It was found that quiescent stem cells in the interfollicular epidermis and hair follicle bulge exhibited specific chromatin modifications, such as high levels of tri-methylated histone H3 at lysine 9 and H4 at lysine 20, and hypoacetylation at histone H4. Myc activation resulted in increased acetylation at histone H4 and a temporary rise in mono-methylation at lysine 20, which was later replaced by di-methylation associated with chromatin silencing. These changes were linked to histone methyltransferases Set8 and Ash-1. The transition from mono- to di-methylated H4K20 required HDAC activity and was inhibited by the HDAC inhibitor trichostatin A (TSA), which also induced a similar epidermal phenotype to Myc activation. The study concluded that Myc-induced chromatin modifications were crucial for the exit of stem cells from their niche.
375 citations
,
February 2006 in “Journal of Cell Science” The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
335 citations
,
March 2004 in “Development” Temporary activation of β-catenin can create new hair follicles, but ongoing activation is needed to keep hair follicle tumors.
421 citations
,
September 2003 in “Development” Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.
94 citations
,
July 2003 in “Journal of biological chemistry/The Journal of biological chemistry” EGF controls hair growth by regulating hair follicles' growth phases.
33 citations
,
April 2003 in “Oncogene” 949 citations
,
January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
1010 citations
,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
252 citations
,
November 1995 in “The EMBO Journal” 745 citations
,
February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
15 citations
,
August 1991 in “Histochemistry and Cell Biology” 409 citations
,
May 1991 in “Genes & Development” TGF-alpha affects skin thickness, hair growth, and may contribute to psoriasis and papilloma formation.
