sPLA2-IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation

    June 2016 in “ Stem cells ”
    Rahul M. Sarate, Gopal Chovatiya, Vagisha Ravi, Bharat Khade, Sanjay Gupta, Sanjeev K. Waghmare
    TLDR Overexpression of sPLA2-IIA in mouse skin reduces hair stem cells and increases cell differentiation through JNK/c-Jun pathway activation.
    The study demonstrated that overexpression of secretory phospholipase A2 group IIA (sPLA2-IIA) in the epidermis of transgenic mice led to the depletion of hair follicle stem cells (HFSCs) and induced differentiation through enhanced activation of the JNK/c-Jun signaling pathway. This overexpression resulted in increased proliferation, altered differentiation, and loss of stem cell quiescence, accompanied by changes in histone modification profiles. These findings suggested that sPLA2-IIA disrupts HFSC maintenance and promotes differentiation, contributing to hair follicle dysfunction and hair loss, with potential implications for understanding hair loss and developing hair therapies.
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