TLDR Phospholipase A2 enzymes play key roles in skin health and disease.
The review article discussed the significant impact of Phospholipase A2 (PLA2) enzymes on skin biology, particularly through their role in lipid metabolism. It highlighted how different PLA2 subtypes, such as sPLA2-IIF, sPLA2-IIE, and sPLA2-IID, influence various aspects of skin health and disease. For instance, sPLA2-IIF was linked to epidermal hyperplasia, while sPLA2-IIE affected hair follicles, and sPLA2-IID influenced cutaneous inflammation through immune cells. The study also touched on the role of PNPLA1 in maintaining skin barrier function. These insights, derived from gene-manipulated mice and lipidomics, suggested new avenues for diagnosing and treating skin diseases.
29 citations,
June 2018 in “Scientific Reports” 15-lipoxygenase helps keep skin healthy by reducing inflammation.
28 citations,
January 2018 in “Biochemical Society Transactions” Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.
408 citations,
February 2017 in “Science” Some wound-healing cells can turn into fat cells around new hair growth in mice.
26 citations,
July 2016 in “Journal of biological chemistry/The Journal of biological chemistry” sPLA2-IIE is crucial for normal hair follicle structure and skin health.
205 citations,
March 2012 in “Science Translational Medicine” PGD2 stops hair growth and is higher in bald men with AGA.
499 citations,
September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
35 citations,
April 2011 in “Journal of Biological Chemistry” sPLA2-X is crucial for normal hair growth and follicle health.
788 citations,
February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
194 citations,
November 2006 in “Science” A genetic mutation in the LIPH gene causes hair loss and growth defects.
