Phospholipase A2 in Skin Biology: New Insights from Gene-Manipulated Mice and Lipidomics

    December 2018 in “ Inflammation and Regeneration ”
    Makoto Murakami, Kei Yamamoto, Yoshitaka Taketomi
    Studysummary This review discusses the roles of various PLA2 enzymes in skin health and disease, highlighting potential pathways for future diagnosis and therapy, but it reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 11

    1. Anti-Inflammatory Role of 15-Lipoxygenase Contributes to the Maintenance of Skin Integrity in Mice Scientific Reports · 2018
    2. Fatty Acids and Related Lipid Mediators in the Regulation of Cutaneous Inflammation Biochemical Society Transactions · 2018
    3. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    4. Expression and Function of Group IIE Phospholipase A2 in Mouse Skin Journal of biological chemistry/˜The œJournal of biological chemistry · 2016
    5. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    6. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    7. LPA-Producing Enzyme PA-PLA1α Regulates Hair Follicle Development by Modulating EGFR Signaling The EMBO Journal · 2011
    8. Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin Journal of Biological Chemistry · 2011
    9. Scratching the Surface of Skin Development Nature · 2007
    10. Human Hair Growth Deficiency Is Linked to a Genetic Defect in the Phospholipase Gene LIPH Science · 2006
    11. Expression of Enhancing Factor/Phospholipase A2 in Skin Results in Abnormal Epidermis and Increased Sensitivity to Chemical Carcinogenesis Oncogene · 2003