Phospholipase A2 in Skin Biology: New Insights from Gene-Manipulated Mice and Lipidomics

December 2018 in “ Inflammation and Regeneration ”

Makoto Murakami, Kei Yamamoto, Yoshitaka Taketomi

Phospholipase A2 PLA2 sPLA2-IIF sPLA2-IIE sPLA2-IID PNPLA1 lipid metabolism epidermal hyperplasia hair follicles cutaneous inflammation immune cells skin barrier function skin barrier skin inflammation

TLDR Phospholipase A2 enzymes play key roles in skin health and disease.

The document discussed the roles of various phospholipase A2 (PLA2) enzymes in skin biology, using gene-manipulated mice and lipidomics. It highlighted that sPLA2-IIF was linked to epidermal hyperplasia and psoriasis, sPLA2-IIE was involved in hair follicle regulation, and sPLA2-IID modulated cutaneous inflammation through immune cells. The study emphasized the importance of understanding specific PLA2-driven lipid pathways for diagnosing and treating skin diseases, noting species differences between mice and humans. Overall, the research suggested potential therapeutic targets for skin-related disorders by targeting specific PLA2 enzymes.

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Research cited in this study

9 / 9 results

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research Expression and Function of Group IIE Phospholipase A2 in Mouse Skin

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sPLA2-IIE is crucial for normal hair follicle structure and skin health.

research Group IID, IIE, IIF, and III Secreted Phospholipase A2s

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