Anti-Inflammatory Role of 15-Lipoxygenase Contributes to the Maintenance of Skin Integrity in Mice
June 2018
in “
Scientific Reports
”
15-lipoxygenase Alox15 hair loss hair follicle stem cells dermal adipocytes fibroblasts proinflammatory macrophage proinflammatory signaling necroptotic signaling dermal adipose tissue resolvin D2 skin inflammation lipidomic analysis 15-LOX fat cells inflammatory macrophage inflammatory signaling cell death signaling skin fat tissue lipid analysis
Studysummary In this study, Alox15 knockout mice exhibited disrupted skin integrity and increased inflammation, suggesting that Alox15-mediated resolvin D2 production is crucial for maintaining skin homeostasis by suppressing inflammation.
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