Anti-Inflammatory Role of 15-Lipoxygenase Contributes to the Maintenance of Skin Integrity in Mice
June 2018
in “
Scientific Reports
”
15-lipoxygenase Alox15 hair loss hair follicle stem cells dermal adipocytes fibroblasts proinflammatory macrophage proinflammatory signaling necroptotic signaling dermal adipose tissue resolvin D2 skin inflammation lipidomic analysis 15-LOX fat cells inflammatory macrophage inflammatory signaling cell death signaling skin fat tissue lipid analysis
TLDR 15-lipoxygenase helps keep skin healthy by reducing inflammation.
The study investigated the anti-inflammatory role of 15-lipoxygenase (Alox15) in maintaining skin integrity in mice. Knockout (KO) of Alox15 led to hair loss, disrupted skin structure, loss of hair follicle stem cells, and abnormal transition of dermal adipocytes into fibroblasts. Alox15 deficiency also increased proinflammatory macrophage infiltration and upregulated proinflammatory and necroptotic signaling in dermal adipose tissue. Lipidomic analysis showed a severe loss of resolvin D2 in Alox15 KO mice, and treatment with resolvin D2 reduced skin inflammation. The results indicated that Alox15-mediated production of resolvin D2 was essential for suppressing dermal inflammation and maintaining skin integrity.
