Fatty Acids and Related Lipid Mediators in the Regulation of Cutaneous Inflammation
January 2018
in “
Biochemical Society Transactions
”
fatty acids lipid mediators cutaneous inflammation sebum lipids sapienic acid essential fatty acids linoleic acid polyunsaturated fatty acids PUFAs bioactive compounds inflammatory skin conditions anti-inflammatory effects bioactive derivatives skin barrier immune response tissue remodeling skin inflammation skin health skin balance dietary supplements immune cell communication
TLDR Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.
The 2018 review article examined the significance of fatty acids and lipid mediators in managing cutaneous inflammation. It explained that the skin's unique fatty acid profile and lipid mediators are essential for skin health, immune response, and inflammation regulation. Sebum lipids, including sapienic acid and others, act as antimicrobial agents and aid in immune cell communication and skin balance. Essential fatty acids, such as linoleic acid, are crucial for the skin barrier, while polyunsaturated fatty acids (PUFAs) lead to various bioactive compounds that are involved in inflammation and tissue remodeling. The review suggested that modifying the skin's fatty acid composition through diet or supplements could help treat inflammatory skin conditions. It also noted that the anti-inflammatory effects of many fatty acids result from their bioactive derivatives, emphasizing the need for further research on these compounds within the skin's metabolic network.
