TLDR SCD1 is crucial for skin health and overall energy balance.
The study investigated the role of Stearoyl-CoA Desaturase-1 (SCD1) in skin integrity and whole-body energy balance using mice models. SCD1-deficient mice exhibited significant skin barrier defects, including severe alopecia and sebocyte hypoplasia, and increased energy expenditure, resistance to diet-induced obesity, and protection against glucose intolerance. These mice also showed changes in skin lipid composition, increased markers of inflammation and wound healing, and altered retinol metabolism. The findings suggested that SCD1 is crucial for maintaining skin integrity and plays a critical role in energy metabolism through complex interactions involving skin lipids, inflammation, and retinol metabolism.
50 citations,
January 2013 in “Indian Journal of Dermatology” Some skin conditions, like psoriasis and early-onset baldness, may indicate metabolic syndrome, and others are linked to diabetes risk and cardiovascular issues.
216 citations,
May 2003 in “Journal of Investigative Dermatology” Glycerol is essential for skin hydration in mice without sebaceous glands.
179 citations,
June 2000 in “The American journal of pathology” The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.
24 citations,
July 2018 in “Stem cells” Runx1 controls fat-related genes important for normal and cancer cell growth, affecting skin and hair cell behavior.
88 citations,
August 2014 in “PLOS genetics” Syndecan-1 is essential for maintaining skin fat and preventing cold stress.
97 citations,
September 2016 in “Reviews in Endocrine and Metabolic Disorders” The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.
21 citations,
November 2022 in “Frontiers in immunology” Sebaceous glands play a key role in skin health, immunity, and various skin diseases.
January 2011 in “Springer eBooks” Eating a balanced diet with the right vitamins and minerals is important for healthy hair, but too many supplements can be harmful.
