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GlossaryStearoyl-CoA Desaturase 1

enzyme converting saturated fatty acids to monounsaturated fatty acids

Stearoyl-CoA Desaturase 1 (SCD1) is an enzyme that plays a crucial role in the metabolism of fatty acids. It converts saturated fatty acids into monounsaturated fatty acids, which are important for maintaining cell membrane fluidity and producing signaling molecules. This enzyme is significant in various biological processes, including lipid metabolism and energy homeostasis, and has been linked to conditions like obesity, diabetes, and certain skin disorders.

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research Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance

67 citations , December 2013 in “Journal of Biological Chemistry”

SCD1 is crucial for skin health and overall energy balance.

research Scd1 ab-Xyk: A New Asebic Allele Characterized by a CCC Trinucleotide Insertion in Exon 5 of the Stearoyl-CoA Desaturase 1 Gene in Mouse

12 citations , July 2004 in “Molecular genetics and genomics”

A new mouse mutation causes skin and hair defects due to a gene change.

research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

25 citations , February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking SCD1 in the skin with XEN103 shrinks sebaceous glands in mice.

research 1H NMR-Based Lipidomics of Rodent Fur: Species-Specific Lipid Profiles and SCD1 Inhibitor-Related Dermal Toxicity

5 citations , April 2014 in “Journal of Lipid Research”

SCD1 inhibitors can cause skin issues in rodents.

research Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography–Mass Spectrometry

71 citations , January 2014 in “Journal of Proteome Research”

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

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