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GlossaryStearoyl-CoA Desaturase 1 (SCD1)

enzyme converting saturated fatty acids to monounsaturated fatty acids

Stearoyl-CoA Desaturase 1 (SCD1) is an enzyme that plays a crucial role in the metabolism of fatty acids. It converts saturated fatty acids into monounsaturated fatty acids, which are important for maintaining cell membrane fluidity and producing signaling molecules. This enzyme is significant in various biological processes, including lipid metabolism and energy homeostasis, and has been linked to conditions like obesity, diabetes, and certain skin disorders.

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Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and SCD1 and SOAT1 Activity

research Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and SCD1 and SOAT1 Activity

24 citations, July 2018 in “Stem cells”

Runx1 controls fat-related genes important for normal and cancer cell growth, affecting skin and hair cell behavior.

research Scd1 ab-Xyk: A New Asebic Allele Characterized by a CCC Trinucleotide Insertion in Exon 5 of the Stearoyl-CoA Desaturase 1 Gene in Mouse

12 citations, July 2004 in “Molecular genetics and genomics”

A new mouse mutation causes skin and hair defects due to a gene change.

research 1H NMR-Based Lipidomics of Rodent Fur: Species-Specific Lipid Profiles and SCD1 Inhibitor-Related Dermal Toxicity

5 citations, April 2014 in “Journal of Lipid Research”

SCD1 inhibitors can cause skin issues in rodents.

Lrig1-Expressing Epidermal Progenitors Require SCD1 to Maintain the Dermal Papilla Niche

research Lrig1-Expressing Epidermal Progenitors Require SCD1 to Maintain the Dermal Papilla Niche

March 2023 in “Scientific reports”

Hair growth-related cells need the enzyme SCD1 to help maintain the area that supports hair growth.

research Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia

179 citations, June 2000 in “The American journal of pathology”

The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.

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