SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes

December 2022 in “ Advanced science ”

Yueqing Xue, Liangyu Lin, Qing Li, Keli Liu, Min Hu, Jiayin Ye, Jiafeng Cao, Jingjie Zhai, Fanjun Zheng, Yu Wang, Tao Zhang, Liming Du, Cheng Gao, Guan Wang, Xuefeng Wang, Jun Qin, Xin‐Hua Liao, Xiangyin Kong, Lydia Sorokin, Yufang Shi, Ying Wang

Stearoyl-CoA Desaturase-1 SCD1 hemidesmosomes basal keratinocytes alopecia PI3K signaling pathway hair follicle stem cells HFSCs oleic acid fatty acid metabolism hair loss PI3K pathway stem cells fat metabolism

TLDR SCD1 is important for hair growth by keeping the connection in skin cells where hair stem cells live stable.

The study reveals that Stearoyl-CoA Desaturase-1 (SCD1) is essential for maintaining the homeostasis of the hair follicle bulge niche by stabilizing hemidesmosomes in basal keratinocytes. SCD1 deficiency in mice leads to alopecia and impaired bulge formation due to disrupted hemidesmosome formation, which enhances keratinocyte proliferation and differentiation via the PI3K signaling pathway. This disruption prevents the formation of the bulge niche, crucial for reserving quiescent hair follicle stem cells (HFSCs). Dietary supplementation with oleic acid, a product of SCD1, restores bulge homeostasis and normalizes hair growth in Scd1−/− mice, suggesting that targeting fatty acid metabolism could be a therapeutic strategy for alopecia and skin aging.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

15 / 15 results

research SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes

4 citations , December 2022 in “Advanced science”

SCD1 is important for hair growth by keeping the connection in skin cells where hair stem cells live stable.

research Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

51 citations , September 2020 in “Cell Metabolism”

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

research Stimulation of Hair Growth by Small Molecules That Activate Autophagy

88 citations , June 2019 in “Cell reports”

Certain small molecules can promote hair growth by activating a cellular cleanup process called autophagy.

research Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration

43 citations , August 2018 in “Cell Stem Cell”

Hoxc genes control hair growth through Wnt signaling.

research Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle

11 citations , October 2017 in “Journal of Investigative Dermatology”

Applying certain inhibitors to the skin can promote hair growth without harming cells.

research Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation

202 citations , August 2017 in “Nature cell biology”

Lactate production is important for activating hair growth stem cells.

research Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations

236 citations , April 2015 in “Cell”

Plucking some hairs can trigger nearby unplucked hairs to grow back more due to a collective response.

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations , August 2014 in “Nature Medicine”

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

research Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair

1235 citations , December 2013 in “Nature”

Two fibroblast types shape skin structure and repair differently.

research Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate

394 citations , October 2013 in “Nature”

research Dissecting the Bulge in Hair Regeneration

86 citations , February 2012 in “Journal of Clinical Investigation”

Stem cells in hair follicles are diverse and change throughout the hair cycle.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations , May 2011 in “Cell stem cell”

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

research Stem Cells and Their Niches

1549 citations , March 2006 in “Science”

Understanding stem cell interactions with their environments is key for advancing regenerative medicine.

research Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia

179 citations , June 2000 in “The American journal of pathology”

The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.

Related Research

3 / 3 results

research Keratinocyte Stem Cells: Role in Aging

1 citations , March 2022 in “IntechOpen eBooks”

Aging reduces skin stem cell function, leading to changes like hair loss and slower wound healing.

research Two- And Three-Dimensional Culture Of Keratinocyte Stem And Precursor Cells Derived From Primary Murine Epidermal Cultures

28 citations , September 2011 in “Stem Cell Reviews and Reports”

research Canine Hair-Follicle Keratinocytes Enriched With Bulge Cells Have the Highly Proliferative Characteristic of Stem Cells

37 citations , October 2009 in “Veterinary Dermatology”

Canine hair follicles contain stem-like cells with high growth potential.