Stimulation of Hair Growth by Small Molecules That Activate Autophagy

The study from June 1, 2019, demonstrated that small molecules activating autophagy, such as α-KG, α-KB, rapamycin, and metformin, could stimulate hair growth by inducing the anagen phase in quiescent hair follicles. This effect was blocked by autophagy inhibitors, indicating a mechanistic link between autophagy and hair regeneration. Increased autophagy was observed during the anagen phase of the natural hair follicle cycle. In aged mice, oral α-KB prevented hair loss, suggesting potential therapeutic applications for hair loss patients. The findings highlighted the possibility of pharmacologically activating anagen in telogen skin, offering new avenues for treating hair loss.