Stimulation of Hair Growth by Small Molecules That Activate Autophagy

    June 2019 in “ Cell reports ”
    Min Chai, Meisheng Jiang, Laurent Vergnes … Jing Huang
    Studysummary This study found that activating autophagy with specific small molecules and drugs can stimulate hair growth by initiating the anagen phase in dormant hair follicles, suggesting a potential treatment for hair loss.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 17

    1. Inactivation of Autophagy Leads to Changes in Sebaceous Gland Morphology and Function Experimental dermatology · 2018
    2. Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture PLOS Biology · 2018
    3. Caloric Restriction Promotes Structural and Metabolic Changes in the Skin Cell Reports · 2017
    4. Metformin Improved Health-Related Quality of Life in Ethnic Chinese Women with Polycystic Ovary Syndrome Health and Quality of Life Outcomes · 2016
    5. Comparison of Clinical and Metabolic Effects of Metformin and Pioglitazone in Polycystic Ovary Syndrome Indian journal of endocrinology and metabolism · 2016
    6. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    7. Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions Journal of Investigative Dermatology · 2015
    8. mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration Journal of molecular cell biology/Journal of Molecular Cell Biology · 2015
    9. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013
    10. Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering Expert Opinion on Biological Therapy · 2013
    11. Mammalian Target of Rapamycin Complex 1 (mTORC1) May Modulate the Timing of Anagen Entry in Mouse Hair Follicles Experimental dermatology · 2012
    12. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    13. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    14. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    15. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    16. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    17. Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993

    Related research 5

    1. What Can Complex Dietary Supplements Do for Hair Loss and How Can It Be Validly Measured: A Review Applied Sciences · 2020
    2. Blockade of S100A3 Activity Inhibits Murine Hair Growth Genetics and Molecular Research · 2015
    3. Alopecia Journal of the Korean Medical Association · 2002
    4. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    5. Treatment of Hair Loss The New England Journal of Medicine · 1999