Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions
March 2015
in “
Journal of Investigative Dermatology
”
mitochondrial function skin epithelium hair follicle morphogenesis epithelial–mesenchymal interactions mitochondrial transcription factor A Tfam hair follicle differentiation hair follicle density sebaceous glands apoptosis cell proliferation immune cell distribution mitochondrial electron transport chain mitochondria skin cells hair follicle development cell interactions hair follicle growth hair follicle count oil glands cell death cell growth immune cells
TLDR Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.
The 2015 study on mice found that mitochondrial function in skin epithelium is crucial for hair follicle development and skin cell interactions. Mice with a deletion of the mitochondrial transcription factor A (Tfam) had impaired hair follicle differentiation, reduced hair follicle density, and did not develop sebaceous glands. These Tfam-deficient mice also showed increased apoptosis, reduced cell proliferation, and abnormalities in immune cell distribution. The study concluded that a functional mitochondrial electron transport chain is essential for the establishment of physiological epithelial–mesenchymal interactions during postnatal murine skin development.
