Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions
March 2015
in “
Journal of Investigative Dermatology
”
![Image of study](/images/research/b8755f24-5024-4777-bfef-9335e8cdd721/medium/12803.jpg)
TLDR Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.
The 2015 study on mice found that mitochondrial function in skin epithelium is crucial for hair follicle development and skin cell interactions. Mice with a deletion of the mitochondrial transcription factor A (Tfam) had impaired hair follicle differentiation, reduced hair follicle density, and did not develop sebaceous glands. These Tfam-deficient mice also showed increased apoptosis, reduced cell proliferation, and abnormalities in immune cell distribution. The study concluded that a functional mitochondrial electron transport chain is essential for the establishment of physiological epithelial–mesenchymal interactions during postnatal murine skin development.
View this study on jidonline.org →
Cited in this study
9 / resultsresearch Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis
P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.
![Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling](/images/research/10754d33-caa6-4724-b181-924633421170/small/19859.jpg)
research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling
Fat-related cells are important for initiating hair growth.
![The mesenchymal component of hair follicle neogenesis: background, methods and molecular characterization](/images/research/ff27173d-e09d-4536-b1b0-12a5de0cf559/small/12208.jpg)
research The mesenchymal component of hair follicle neogenesis: background, methods and molecular characterization
The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.
![The Hair Follicle as a Dynamic Miniorgan](/images/research/fbec182b-53ae-4ec9-9333-1d61568e55fd/small/12868.jpg)
research The Hair Follicle as a Dynamic Miniorgan
Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
![Hair growth stimulatory effect by a combination of 5-aminolevulinic acid and iron ion](/images/research/6edc0221-f533-44ac-a2d4-2ae48e50dfd7/small/15058.jpg)
research Hair growth stimulatory effect by a combination of 5-aminolevulinic acid and iron ion
A mix of 5-aminolevulinic acid and iron ion can speed up hair growth.
![Scratching the surface of skin development](/images/research/b91b57e2-31b9-4ad0-9fdf-53d88fee824d/small/19992.jpg)
research Scratching the surface of skin development
The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
![A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice](/images/research/85b94511-93a7-4f5d-884a-27a7badfdbd5/small/20010.jpg)
research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice
The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.
research Epithelial growth control by neurotrophins: leads and lessons from the hair follicle
Neurotrophins are important for hair growth and could help treat hair loss.
![Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone.](/images/research/0ab7af6c-eec6-4284-888e-ee97b2e65aec/small/22708.jpg)
research Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone.
Cyclosporine A slows down hair loss from chemotherapy in mice, while dexamethasone increases hair loss but speeds up regrowth.
Related
4 / results![Endogenous Human Skin Equivalent Promotes In Vitro Morphogenesis of Follicle-Like Structures](/images/research/e2f344d3-bd14-40ea-9916-7056c19c7b6f/small/34349.jpg)
research Endogenous Human Skin Equivalent Promotes In Vitro Morphogenesis of Follicle-Like Structures
Endo-HSE helps grow hair-like structures from human skin cells in the lab.
![Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling](/images/research/34b1c5fa-5387-4fb7-9688-c3f07f78fe1e/small/19818.jpg)
research Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling
The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.
![Dynamic Signals for Hair Follicle Development and Regeneration](/images/research/e842b782-08fc-498a-966e-a0da144707fb/small/12849.jpg)
research Dynamic Signals for Hair Follicle Development and Regeneration
Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.
![β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair](/images/research/f22ee802-ae0e-43cf-84ca-3528bdd5f498/small/19905.jpg)
research β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
β-catenin in the dermal papilla is crucial for normal hair growth and repair.