Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis

    January 2013 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Liat Samuelov, Eli Sprecher, Koji Sugawara, Suman Kumar Singh, Desmond J. Tobin, Daisuke Tsuruta, Tamás Bı́ró, Jennifer E. Kloepper, Ralf Paus
    TLDR P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.
    The study demonstrated that P-cadherin played a crucial role in regulating human hair follicle melanogenesis, but not epidermal pigmentation. Silencing P-cadherin in hair follicles led to significant reductions in melanin content, tyrosinase activity, and the expression of key melanogenic markers such as gp100, stem cell factor, c-Kit, and MITF. This effect was mediated through the GSK3β/Wnt pathway. The findings suggested potential therapeutic strategies for modulating hair pigmentation and provided insights into the pathobiological consequences of CDH3 gene mutations in related syndromes. The study involved re-analysis of hair follicles from five patients.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 351 results

      community Looking for Latanoprost sources EU

      in Product  2 upvotes 1 year ago
      The user has been using MinoxidilMax Latanoprost 0.01% and noticed an increase in hair density after years of stability on finasteride and minoxidil. They are seeking help to find a higher dosage of Latanoprost or a reliable source to purchase the powder to make their own, without a prescription or high cost.

      community Ru-58841 vs KX-826/pyrilutamide while on steroids

      in Finasteride/Dutasteride  3 upvotes 3 weeks ago
      The user increased their steroid dosage and noticed hair shedding, so they adjusted their regimen by reducing steroid doses and adding oral dutasteride. They are also experimenting with combining RU-58841 and KX-826/pyrilutamide in minoxidil to address hair loss.

      community [26M] 3.5 year update. Fin+Min

      in Progress Pictures  3399 upvotes 4 months ago
      A user shared their 3.5-year hair loss treatment journey using finasteride and minoxidil, showing significant hair density improvement and no noticeable side effects. The user also mentioned the confidence boost from shaving their head and the positive impact of the treatments.

    Similar Research

    5 / 1000+ results