Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis

    January 2013 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Liat Samuelov, Eli Sprecher, Koji Sugawara, Suman Kumar Singh, Desmond J. Tobin, Daisuke Tsuruta, Tamás Bı́ró, Jennifer E. Kloepper, Ralf Paus
    TLDR P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.
    The study demonstrated that P-cadherin played a crucial role in regulating human hair follicle melanogenesis, but not epidermal pigmentation. Silencing P-cadherin in hair follicles led to significant reductions in melanin content, tyrosinase activity, and the expression of key melanogenic markers such as gp100, stem cell factor, c-Kit, and MITF. This effect was mediated through the GSK3β/Wnt pathway. The findings suggested potential therapeutic strategies for modulating hair pigmentation and provided insights into the pathobiological consequences of CDH3 gene mutations in related syndromes. The study involved re-analysis of hair follicles from five patients.
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