Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation

    Carina Nicu, James D B O'Sullivan, Raúl Ramos, Ludovica Timperi, Tiffany Lai, Nilofer Farjo, Bessam Farjo, Jenny Pople, Ranjit Bhogal, Jonathan A. Hardman, Maksim V. Plikus, David M. Ansell, Ralf Paus
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    TLDR Fat under the skin releases HGF which helps hair grow and gain color.
    The study "Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation" investigates the role of dermal white adipose tissue (dWAT) in hair growth and pigmentation. The research, involving 4 male donors and 4 donors (2 female and 2 male), found that dWAT secretes Hepatocyte Growth Factor (HGF), which promotes hair growth and pigmentation. HGF stimulates melanocyte numbers, melanogenesis, and hair matrix proliferation, and activates Wnt signaling within the hair follicle, associated with hair growth. The study concludes that dWAT-secreted HGF plays a key role in promoting hair growth and pigmentation, making dWAT and HGF important targets for therapeutic intervention in human hair growth and pigmentation disorders.
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