Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

    March 2019 in “ Experimental Dermatology
    Mi Hee Kwack, Chang Ho Seo, Prakash Gangadaran, Byeong-Cheol Ahn, Moon S. Kim, Jung Hyun Kim, Young Chul Sung
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    TLDR Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.
    In 2019, Prof. Young-Kwan Sung led a study that discovered exosomes derived from human dermal papilla cells (DP cells) can stimulate hair growth and regeneration. The research showed that these exosomes, when derived from 3D cultured DP cells, increased the proliferation of DP cells and outer root sheath cells, and boosted the expression of growth factors in DP cells. They also extended the length of the hair shaft in cultured human hair follicles and triggered the active growth phase of hair follicles in mice. When used in human DP spheres, these exosomes enhanced hair follicle neogenesis. The study concluded that these exosomes could potentially be used in therapeutic strategies for hair loss.
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