Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)?

    December 1998 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Desmond J. Tobin, Edward H. Hagen, Vladimir A. Botchkarev, Ralf Paus
    TLDR Hair follicle melanocytes die during hair regression.
    The study investigated the fate of hair follicle melanocytes during the anagen-catagen transition in C57BL/6 mice, finding that melanocytes undergo apoptosis during both spontaneous and pharmacologically induced catagen. Apoptosis was more frequent in dexamethasone-induced catagen, while cyclophosphamide-induced catagen showed severe melanocyte incontinence and ectopic melanin distribution. The results suggested that apoptosis contributes to the loss of melanogenic melanocytes during catagen, with different catagen models providing insights into hair pigmentation and melanocyte response to chemical injury.
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