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GlossaryCyclophosphamide

chemotherapy drug that interferes with DNA replication in cells

Cyclophosphamide, also known as Cytoxan, is a chemotherapy drug used to treat various types of cancer and certain autoimmune diseases. It works by interfering with the DNA replication process in rapidly dividing cells, which helps to slow or stop the growth of cancer cells. However, it can also affect healthy cells, leading to side effects such as hair loss (alopecia) and increased risk of infections.

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research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

106 citations, June 2005 in “Journal of Investigative Dermatology”

The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.

research Cyclophosphamide and Rituximab in Frequently Relapsing/Steroid-Dependent Nephrotic Syndrome

39 citations, November 2015 in “Pediatric Nephrology”

Rituximab leads to longer remission and fewer side effects than cyclophosphamide.

Cyclophosphamide: As Bad as Its Reputation? Long-Term Single Centre Experience of Cyclophosphamide Side Effects in the Treatment of Systemic Autoimmune Diseases

research Cyclophosphamide: As Bad as Its Reputation? Long-Term Single Centre Experience of Cyclophosphamide Side Effects in the Treatment of Systemic Autoimmune Diseases

39 citations, October 2014 in “Schweizerische medizinische Wochenschrift”

Cyclophosphamide has serious side effects, but long-term follow-up can help manage risks.

Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

research Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

36 citations, April 1994 in “PubMed”

Cyclosporine A slows down hair loss from chemotherapy in mice, while dexamethasone increases hair loss but speeds up regrowth.

research Treatment with ImuVert and N-Acetylcysteine Protects Rats from Cyclophosphamide and Cytarabine-Induced Alopecia

26 citations, January 1992 in “Cancer investigation”

N-acetylcysteine and ImuVert can prevent hair loss in rats caused by chemotherapy.

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