Stem Cell Factor/c-Kit Signaling in Normal and Androgenetic Alopecia Hair Follicles

    January 2008 in “ Journal of Endocrinology
    Valerie A. Randall, Tracey J. Jenner, Nigel A. Hibberts, Isabel O De Oliveira, Tayyebeh Vafaee
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    TLDR SCF and c-Kit decrease in AGA hair follicles, possibly affecting hair pigmentation and growth.
    This 15-year-old scientific paper explores the role of stem cell factor (SCF) and c-Kit signaling in hair follicles, specifically in relation to hair pigmentation in normal and androgenetic alopecia (AGA) follicles. The study found that SCF and c-Kit expression were decreased in AGA hair follicles compared to normal hair follicles, suggesting that this signaling pathway may play a role in the pathogenesis of AGA. They also suggest that targeting this pathway may be a potential therapeutic approach for AGA. The study was conducted on 23 individuals.
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