Hair Melanocytes as Neuro-Endocrine Sensors—Pigments for Our Imagination

The document discussed the role of hair follicles as neuro-endocrine sensors, highlighting their ability to produce and respond to various neuropeptides and hormones. It emphasized the skin's capacity to act as a peripheral neuro-endocrine organ, particularly through the production of corticotropin-releasing hormone (CRH) and pro-opiomelanocortin (POMC) peptides, which regulate pigmentation in hair follicles. The study underscored the importance of the skin's stress defense system, which relies on locally-produced melanocortins to neutralize harmful stimuli, thereby protecting the organism.