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    Glossary Proopiomelanocortin

    precursor protein cleaved into hormones affecting pigmentation and stress

    Proopiomelanocortin (POMC) is a large precursor protein that is produced in the pituitary gland and other tissues. It is cleaved into several important hormones, including adrenocorticotropic hormone (ACTH), which regulates cortisol production, and melanocyte-stimulating hormones (MSH), which influence skin pigmentation and hair growth.

    Research 10 of 241

    1. Proopiomelanocortin expression in the skin during induced hair growth in mice Experientia · 1992 · 118 citations
    2. Proopiomelanocortin (POMC) and Psychodermatology Skin Health and Disease · 2023 · 11 citations
    3. A Founder Mutation in the <i>POMC</i> 5′-UTR Causes Proopiomelanocortin Deficiency Through Splicing-Mediated Decrease of mRNA The Journal of Clinical Endocrinology & Metabolism · 2022 · 4 citations
    4. Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol The FASEB Journal · 2005 · 489 citations
    5. Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth 1993 · 210 citations
    6. The human skin as a hormone target and an endocrine gland Hormones · 2004 · 146 citations
    7. Neuroendocrinology of the hair follicle: principles and clinical perspectives Trends in Molecular Medicine · 2014 · 98 citations
    8. Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of α-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells Endocrinology · 2005 · 60 citations
    9. Spatiotemporal Expression, Distribution, and Processing of POMC and POMC-derived Peptides in Murine Skin Journal of Histochemistry & Cytochemistry · 2000 · 49 citations
    10. Hair melanocytes as neuro-endocrine sensors—Pigments for our imagination Molecular and cellular endocrinology · 2005 · 43 citations
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