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    Glossary Proopiomelanocortin

    precursor protein cleaved into hormones affecting pigmentation and stress

    Proopiomelanocortin (POMC) is a large precursor protein that is produced in the pituitary gland and other tissues. It is cleaved into several important hormones, including adrenocorticotropic hormone (ACTH), which regulates cortisol production, and melanocyte-stimulating hormones (MSH), which influence skin pigmentation and hair growth.

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    Research 30 of 208

    1. Proopiomelanocortin expression in the skin during induced hair growth in mice Experientia · 1992 · 118 citations
    2. Proopiomelanocortin (POMC) and Psychodermatology Skin Health and Disease · 2023 · 11 citations
    3. A Founder Mutation in the <i>POMC</i> 5′-UTR Causes Proopiomelanocortin Deficiency Through Splicing-Mediated Decrease of mRNA The Journal of Clinical Endocrinology & Metabolism · 2022 · 4 citations
    4. Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol The FASEB Journal · 2005 · 489 citations
    5. Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth 1993 · 210 citations
    6. The human skin as a hormone target and an endocrine gland Hormones · 2004 · 146 citations
    7. Neuroendocrinology of the hair follicle: principles and clinical perspectives Trends in Molecular Medicine · 2014 · 98 citations
    8. Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of α-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells Endocrinology · 2005 · 60 citations
    9. Spatiotemporal Expression, Distribution, and Processing of POMC and POMC-derived Peptides in Murine Skin Journal of Histochemistry & Cytochemistry · 2000 · 49 citations
    10. Hair melanocytes as neuro-endocrine sensors—Pigments for our imagination Molecular and cellular endocrinology · 2005 · 43 citations
    11. Melanocortins in fibroblast biology – current update and future perspective for dermatology Experimental Dermatology · 2004 · 32 citations
    12. Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways British Journal of Dermatology · 2017 · 27 citations
    13. The local hypothalamic–pituitary–adrenal axis in cultured human dermal papilla cells BMC Molecular and Cell Biology · 2020 · 9 citations
    14. The human hair follicle has established a fully functional peripheral equivalent of the hypothamalic‐pituitary‐adrenal‐axis (HPA) Experimental Dermatology · 2005 · 9 citations
    15. Corticotropin-Releasing Factor Down-Regulates Hair Growth-Related Cytokines in Cultured Human Dermal Papilla Cells Journal of the Society of Cosmetic Scientists of Korea · 2014 · 1 citations
    16. The local hypothalamic–pituitary–adrenal axis in cultured human dermal papilla cells Research Square (Research Square) · 2020
    17. The local hypothalamic–pituitary–adrenal axis in cultured human dermal papilla cells Research Square (Research Square) · 2020
    18. BJD Snippet Journal of Cosmetic Dermatology · 2017
    19. Local Actions of Thyrotropin-Releasing Hormone Regulate Hair Color Journal of Investigative Dermatology · 2011
    20. A neuroendocrinological perspective on human hair follicle pigmentation Pigment Cell & Melanoma Research · 2010 · 56 citations
    21. SASH1 Mutations and Hereditary Disorders of Pigmentation: Review of Literature Pigment Cell & Melanoma Research · 2025 · 1 citations
    22. CD44 signaling in skin wound healing and regeneration Journal of Translational Medicine · 2025 · 8 citations
    23. Hair follicle immune privilege and its collapse in alopecia areata Experimental dermatology · 2020 · 134 citations
    24. Serotoninergic and melatoninergic systems are fully expressed in human skin ˜The œFASEB journal · 2002 · 249 citations
    25. Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases Pharmacological Reports · 2023 · 47 citations
    26. Alopecia areata – hyperactivity of the hypothalamic–pituitary–adrenal axis is a myth? Journal of the European Academy of Dermatology and Venereology · 2017 · 5 citations
    27. Hair greying & its palliative management Southeast Asian journal of health professionals · 2022
    28. Dermatological Maifestations of Obesity Journal of medical science and clinical research · 2017
    29. Neuroimmunology of Stress: Skin Takes Center Stage Journal of Investigative Dermatology · 2006 · 375 citations
    30. Sex differences in the hypothalamic–pituitary–adrenal axis’ response to stress: an important role for gonadal hormones Neuropsychopharmacology · 2019 · 197 citations