Pathogenesis and Regenerative Therapy in Vitiligo and Alopecia Areata: Focus on Hair Follicle

    January 2025 in “ Frontiers in Medicine ”
    Yuan Zhou, Yu-Xuan Zhang, Yuyun Xiong, Yumei Li
    Studysummary This study reviews the role of hair follicles in the development, symptoms, and treatment options for vitiligo and alopecia areata, aiming to enhance understanding of their involvement in these autoimmune conditions and explore potential therapies.
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    Research cited in this study 31

    1. Innovative Strategies for the Discovery of New Drugs Against Alopecia Areata: Taking Aim at the Immune System Expert Opinion on Drug Discovery · 2024
    2. Safety and Efficacy of Tofacitinib in 97 Alopecia Areata Patients Journal of cosmetic dermatology · 2024
    3. Autophagy Induces Hair Follicle Stem Cell Activation and Hair Follicle Regeneration by Regulating Glycolysis 2024
    4. Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration 2024
    5. Status of Research on the Development and Regeneration of Hair Follicles International Journal of Medical Sciences · 2023
    6. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    7. Applications of Human Pluripotent Stem Cell-Derived Skin Organoids in Dermatology ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    8. Diagnosis and Differential Diagnosis of Tertiary Androgenetic Alopecia With Severe Alopecia Areata Based on High-Resolution MRI Skin Research and Technology · 2023
    9. IPSC-Based Approach for Human Hair Follicle Regeneration Frontiers in Cell and Developmental Biology · 2023
    10. Novel Potential Therapeutic Targets of Alopecia Areata Frontiers in Immunology · 2023
    11. Hypoxia Enhances the Hair Growth-Promoting Effects of Embryonic Stem Cell-Derived Mesenchymal Stem Cells Via NADPH Oxidase 4 Biomedicine & Pharmacotherapy · 2023
    12. Generation And Characterization Of Hair-Bearing Skin Organoids From Human Pluripotent Stem Cells Nature Protocols · 2022
    13. Whole Exome Sequencing in Alopecia Areata Identifies Rare Variants in KRT82 Nature communications · 2022
    14. Successful Follicular Unit Extraction in a Case of Inactive, Recalcitrant Alopecia Barbae Dermatologic Therapy · 2021
    15. Regenerative Medicine Treatments for Androgenetic Alopecia Indian Journal of Plastic Surgery · 2021
    16. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    17. Updates and new medical treatments for vitiligo (Review) Experimental and Therapeutic Medicine · 2021
    18. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    19. Follicular Unit Transplantation Facial Plastic Surgery Clinics of North America · 2020
    20. Follicular Unit Extraction (FUE) Hair Transplant: Curves Ahead Journal of Maxillofacial and Oral Surgery · 2019
    21. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    22. Skin Equivalent Assay: An Optimized Method for Testing Hair Growth Reconstitution Capacity of Epidermal and Dermal Cells Experimental Dermatology · 2019
    23. Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Dermatology · 2018
    24. Regulation of Melanocyte Stem Cells in the Pigmentation of Skin and Its Appendages: Biological Patterning and Therapeutic Potentials Experimental Dermatology · 2018
    25. Regulation of Melanocyte Stem Cell Behavior by the Niche Microenvironment Pigment Cell & Melanoma Research · 2018
    26. Aging, Alopecia, and Stem Cells Science · 2016
    27. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    28. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    29. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    30. Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata Journal of Clinical Investigation · 2007
    31. Single Hair Grafting for the Treatment of Vitiligo Journal of The American Academy of Dermatology · 1998

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    1. Progenic Hair Regrowth Treatment: The Use of Platelet-Released Growth Factors for Treating Androgenetic Alopecia by Activating Hair Follicle Stem Cells Journal of clinical & experimental dermatology research · 2014
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