Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche

A specific signal from hair cells controls the tightening of the surrounding muscle, which is necessary for hair shedding.

Aging changes hair stem cells and their environment, leading to gray hair and hair thinning, but understanding these changes could help develop treatments for hair regeneration.

Outdoor living and omega-3 supplements improve rabbit fur quality.

Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.

The Bcl-2 protein is important for keeping hair follicle stem cells working and preventing hair loss.

Hair follicle stem cells help maintain skin health and could improve skin replacement therapies.

Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

SIRT7 protein is crucial for starting hair growth in mice.

Muscles and nerves that cause goosebumps also help control hair growth.

Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.

Aging scalp skin contributes to hair aging and loss, and more research is needed to develop better hair loss treatments.

Genes related to pigmentation, body rhythms, and behavior change during hares' seasonal coat color transition, with a common genetic mechanism in two hare species.

Timing of light therapy affects horse coat growth, with photoperiod being crucial.

Lymphatic vessels are essential for hair follicle growth and skin regeneration.

Hair becomes gray and thin as we age, and while most hair loss in older people is due to genetics, there's a chance for gray hair to regain color under certain conditions.

Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.

The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.

Hoxc genes control hair growth through Wnt signaling.

Light can turn on hair growth cells through a nerve path starting in the eyes.

Different types of skin cells play specific roles in development, healing, and cancer.

Lactate production is important for activating hair growth stem cells.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

Transit-amplifying cells are crucial for tissue repair and can contribute to cancer when they malfunction.

Correcting nutrient deficiencies may help with hair loss, but the benefits of supplements without a deficiency are uncertain and could be harmful.

Some wound-healing cells can turn into fat cells around new hair growth in mice.

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

The document concludes that both internal stem cell factors and external influences like the environment and hormones affect hair loss and aging, with potential treatments focusing on these areas.

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.

Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.

BMAL1 and Period1 genes can influence human hair growth.

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

Aging causes skin stem cells to work less effectively.

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

BMAL1 controls skin cell growth and UV damage risk, peaking at night.

Hair regeneration needs dynamic cell behavior and mesenchyme presence for stem cell activation.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

Different hair follicles in the skin are innervated by unique combinations of mechanosensory neurons, crucial for touch sensation.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

Fat-related cells are important for initiating hair growth.

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

Nephronectin helps attach muscle cells to hair follicles.

Scientists found a new, less invasive way to study body clocks using hair cells, which shows shift workers' body clocks don't match their lifestyles.

Certain groups may need vitamin supplements to improve hair health and prevent other health problems.

Marie Antoinette syndrome causes sudden hair whitening, but its exact cause is unknown.

Over one-third of women experience hair loss, with female-pattern hair loss being most common, and treatments include minoxidil and possibly hair transplantation.

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

Prolactin slows down hair growth in mice.

Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.

Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

Neurotrophins are important for hair growth and could help treat hair loss.

BMP receptor IA is essential for proper hair cell differentiation in mice.

Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

Hair follicle biology advancements may lead to better hair growth disorder treatments.

Manipulating the catagen and telogen phases of hair growth could lead to treatments for hair disorders.

Hair follicles create different cell layers and proteins, controlled by various molecules.

Hair growth is cyclic and influenced mainly by local factors.