Prolactin Delays Hair Regrowth in Mice

November 2006 in “ Journal of Endocrinology ”

A. J. Craven, A. J. Nixon, M. G. Ashby, Christopher J. Ormandy, Katrina Blazek, Richard J. Wilkins, A. J. Pearson

prolactin prolactin receptor anagen phase bromocriptine hair follicle cycling prolactin receptor mRNA prolactin receptor-deficient mice hair regrowth Parlodel

Studysummary This study found that prolactin plays a direct role in regulating the timing of hair growth cycles in mice by affecting the skin, rather than through other endocrine factors.

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Research cited in this study

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Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

128 citations , March 2006 in “American Journal of Pathology”

The study found that prolactin expressed in human scalp hair follicles acts as an autocrine modulator, inhibiting hair growth and promoting hair follicle regression, which may contribute to hair loss in hyper-prolactinemia patients.

Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

research Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

91 citations , May 2003 in “American Journal of Pathology”

This study found that prolactin and its receptor are expressed in the murine hair follicle epithelium, influencing hair cycle phases by down-regulating keratinocyte proliferation during anagen and inducing premature catagen.

research Molecular Genetic and Endocrine Mechanisms of Hair Growth

51 citations , January 2003 in “Hormone Research in Paediatrics”

This review discusses hormonal influences on hair growth and suggests that understanding hormone-gene interactions may improve treatment of hirsutism and alopecia, but reports no new clinical findings.

research Exogen, Shedding Phase of the Hair Growth Cycle: Characterization of a Mouse Model

107 citations , September 2002 in “Journal of Investigative Dermatology”

This study identified a distinct "exogen" phase in the hair cycle during which hair shedding occurs, primarily coupled with the anagen phase, rather than as part of the telogen phase.

Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice

research Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice

73 citations , June 2001 in “Endocrinology”

In this study, researchers found that disrupting the PRL gene in mice led to earlier hair molting, especially in females, suggesting that PRL inhibits murine hair cycle events.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.

research 17β-Estradiol and ICI-182780 Regulate the Hair Follicle Cycle in Mice Through an Estrogen Receptor-α Pathway

71 citations , February 2000 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism”

This study found that topical estradiol inhibits hair growth in mice by preventing the hair follicle's transition from resting to growth phase, a process reversible with an estrogen receptor antagonist.

research The Skin POMC System (SPS): Leads and Lessons from the Hair Follicle

66 citations , October 1999 in “Annals of the New York Academy of Sciences”

This article discusses the potential role of a local skin POMC system in the murine hair cycle and cutaneous stress responses, with no new results presented.

research An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation

154 citations , October 1996 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that 17-beta-estradiol inhibits hair growth in mice by blocking hair follicles in the telogen phase, whereas an estrogen receptor antagonist promotes hair growth by initiating anagen.

research The Microanatomy, Cell Replication, and Keratin Gene Expression of Hair Follicles During a Photoperiod-Induced Growth Cycle in Sheep

20 citations , January 1995 in “Cells tissues organs”

The researchers reported that exposure to long days after short-day treatment induced a synchronized, out-of-season wool growth cycle in New Zealand Wiltshire sheep, similar to cycles induced in other species.

research The Role of Prolactin in the Reactivation of Hair Follicles in Relation to Moulting in Cashmere Goats

62 citations , December 1994 in “Journal of Endocrinology/Journal of endocrinology”

In this study, administrating ovine prolactin accelerated secondary hair follicle reactivation and moulting in cashmere goats, while bromocriptine delayed these processes.

research Fiber Growth Initiation in Hair Follicles of Goats Treated with Melatonin

48 citations , September 1993 in “The journal of experimental zoology/Journal of experimental zoology”

In this study, melatonin implants advanced and synchronized spring hair growth in goats by initiating fiber growth earlier than in untreated goats, with associated suppression of normal prolactin rise.

research Glucocorticoid Effect on Hair Growth Initiation: A Reconsideration

77 citations , January 1993 in “Skin Pharmacology and Physiology”

In this study, topically applied glucocorticosteroids were found to block hair growth at the stage of hair formation, but not the initiation of hair growth, in a mouse model.

research Does Prolactin Play a Role in Skin Biology and Pathology?

41 citations , September 1991 in “Medical hypotheses”

This article reviews the potential role of prolactin as a neuroendocrine modulator in skin biology and pathology, discussing its relevance for conditions such as psoriasis and hair growth, but reports no new clinical findings.

research Disorder of Hair Growth in Hyperprolactinemia

3 citations , January 1988 in “PubMed”

This study observed that functional hyperprolactinemia in several women was associated with skin symptoms such as seborrhea, acne, and hair-related issues, resembling androgen-induced conditions.

research The Endocrine System and Hair Growth in the Rat

28 citations , March 1942 in “Journal of Endocrinology”

This article reviews studies on thyroid influence on hair growth, noting varied results, including accelerated growth in some normal and underfed rats after thyroid administration, but reports no clinical results.