Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

    March 2006 in “ American Journal of Pathology ”
    Kerstin Foitzik, Karoline Krause, Franziska Conrad … Ralf Paus
    Studysummary The study found that prolactin expressed in human scalp hair follicles acts as an autocrine modulator, inhibiting hair growth and promoting hair follicle regression, which may contribute to hair loss in hyper-prolactinemia patients.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on ajp.amjpathol.org →
    Discuss this study in the Community →

    Research cited in this study 12

    1. Hormonal Basis of Male and Female Androgenic Alopecia: Clinical Relevance Skin Pharmacology and Physiology · 2009
    2. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005
    3. Acne and Sebaceous Gland Function Clinics in dermatology · 2004
    4. Hormonal Profile of Men with Premature Balding Experimental and Clinical Endocrinology & Diabetes · 2004
    5. Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen American Journal of Pathology · 2003
    6. Molecular Genetic and Endocrine Mechanisms of Hair Growth Hormone Research in Paediatrics · 2003
    7. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    8. Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice Endocrinology · 2001
    9. Growth of Secondary Hair Follicles of the Cashmere Goat In Vitro and Their Response to Prolactin and Melatonin PubMed · 1994
    10. Human Hair Growth In Vitro: A Model for the Study of Hair Follicle Biology Journal of Dermatological Science · 1994
    11. Does Prolactin Play a Role in Skin Biology and Pathology? Medical hypotheses · 1991
    12. Hormonal Diagnosis of So-Called Androgenetic Alopecia in Women Geburtshilfe und Frauenheilkunde · 1988