Mind the Gender Gap: Does Prolactin Exert Gender and Site-Specific Effects on the Human Hair Follicle?

    November 2009 in “ Journal of Investigative Dermatology ”
    Ewan A. Langan, Yuval Ramot, Vincent Goffin … Ralf Paus
    Studysummary This study suggests that prolactin has complex, gender- and location-dependent effects on human hair follicles, promoting hair growth in female frontotemporal scalp areas while inhibiting it in male occipital regions.
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    Research cited in this study 12

    1. Prolactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone Journal of Investigative Dermatology · 2008
    2. Androgens and Hair Growth Dermatologic Therapy · 2008
    3. Prolactin Delays Hair Regrowth in Mice Journal of Endocrinology · 2006
    4. Telogen Effluvium Associated with the Dopamine Agonist Pramipexole in a 55-Year-Old Woman with Parkinson's Disease Journal of The American Academy of Dermatology · 2006
    5. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    6. Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression American Journal of Pathology · 2006
    7. Substantial Sex-Dependent Differences in the Response of Human Scalp Hair Follicles to Estrogen Stimulation In Vitro Advocate Gender-Tailored Management of Female Versus Male Pattern Balding Journal of Investigative Dermatology Symposium Proceedings · 2005
    8. Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen American Journal of Pathology · 2003
    9. Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice Endocrinology · 2001
    10. The Role of Prolactin in the Reactivation of Hair Follicles in Relation to Moulting in Cashmere Goats Journal of Endocrinology/Journal of endocrinology · 1994
    11. Does Prolactin Play a Role in Skin Biology and Pathology? Medical hypotheses · 1991
    12. Human Hair Growth In Vitro Journal of Cell Science · 1990