TLDR Human scalp hair follicles can be used to study how prolactin affects hair growth and cell death.
The document discussed the role of prolactin (PRL) in human hair follicles (HFs) and its potential as a model to study PRL's autocrine/paracrine activities. It highlighted that PRL is produced in extrapituitary sites, including HFs, where it could inhibit hair growth and promote apoptosis. The authors suggested that human scalp HFs could serve as a relevant model to investigate PRL regulation and its effects, given their similarities to pituitary PRL regulation. They also noted the need to explore dopamine receptor expression in HFs to understand its impact on PRL synthesis and release.
Cited in this study
6 / 6 results
51 citations
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September 2010 in “Trends in Endocrinology and Metabolism” Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.
37 citations
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March 2010 in “British Journal of Dermatology” Oestrogen and thyrotropin-releasing hormone affect prolactin and its receptor in human skin and hair, suggesting new treatment options for related conditions.
36 citations
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March 2010 in “Journal of Investigative Dermatology” Prolactin may affect hair growth differently based on gender and scalp area.
64 citations
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January 2010 in “The FASEB Journal” Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.
128 citations
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March 2006 in “American Journal of Pathology” Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.
91 citations
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May 2003 in “American Journal of Pathology” Prolactin affects hair growth cycles and can cause early hair follicle regression.
