Utilizing the Hair Follicle to Dissect the Regulation and Autocrine/Paracrine Activities of Prolactin in Humans

    Ewan A. Langan, C.E.M. Griffiths, Ralf Paus
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    TLDR Human scalp hair follicles can be used to study how prolactin affects hair growth and cell death.
    The document discussed the role of prolactin (PRL) in human hair follicles (HFs) and its potential as a model to study PRL's autocrine/paracrine activities. It highlighted that PRL is produced in extrapituitary sites, including HFs, where it could inhibit hair growth and promote apoptosis. The authors suggested that human scalp HFs could serve as a relevant model to investigate PRL regulation and its effects, given their similarities to pituitary PRL regulation. They also noted the need to explore dopamine receptor expression in HFs to understand its impact on PRL synthesis and release.
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