Utilizing the Hair Follicle to Dissect the Regulation and Autocrine/Paracrine Activities of Prolactin in Humans

May 2012 in “ Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism ”

Ewan A. Langan, C.E.M. Griffiths, Ralf Paus

prolactin hair follicles autocrine paracrine apoptosis dopamine receptor hair growth PRL HFs

TLDR Human scalp hair follicles can be used to study how prolactin affects hair growth and cell death.

The document discussed the role of prolactin (PRL) in human hair follicles (HFs) and its potential as a model to study PRL's autocrine/paracrine activities. It highlighted that PRL is produced in extrapituitary sites, including HFs, where it could inhibit hair growth and promote apoptosis. The authors suggested that human scalp HFs could serve as a relevant model to investigate PRL regulation and its effects, given their similarities to pituitary PRL regulation. They also noted the need to explore dopamine receptor expression in HFs to understand its impact on PRL synthesis and release.

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Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

128 citations, March 2006 in “American Journal of Pathology”

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research Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

91 citations, May 2003 in “American Journal of Pathology”

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research Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

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Utilizing the Hair Follicle to Dissect the Regulation and Autocrine/Paracrine Activities of Prolactin in Humans

Research cited in this study

research Endocannabinoids Limit Excessive Mast Cell Maturation And Activation In Human Skin

research Prolactin: An Emerging Force Along the Cutaneous–Endocrine Axis

research Thyrotropin-Releasing Hormone and Estrogen Differentially Regulate Prolactin and Prolactin Receptor Expression in Female Human Skin and Hair Follicles In Vitro

research Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ

research Mind the Gender Gap: Does Prolactin Exert Gender and Site-Specific Effects on the Human Hair Follicle?

research Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture

research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

research Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

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