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research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factors in Response to Testosterone Unlike Scalp Cells

51 citations, November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Beard cells, unlike scalp cells, produce growth factors in response to testosterone, which may explain differences in hair growth.

To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

research To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

23 citations, May 2016 in “American Journal of Pathology”

The research suggests that a specific skin gene can be controlled by signals within and between cells and is wrongly activated in certain skin diseases.

research Utilizing the Hair Follicle to Dissect the Regulation and Autocrine/Paracrine Activities of Prolactin in Humans

12 citations, May 2012 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism”

Human scalp hair follicles can be used to study how prolactin affects hair growth and cell death.

research Unexpected Autocrine Role of Vascular Endothelial Growth Factor in Squamous Cell Carcinoma

1 citations, February 2009 in “Journal of Investigative Dermatology”

VEGF helps squamous cell carcinoma grow in ways beyond just blood vessel formation.

Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

128 citations, March 2006 in “American Journal of Pathology”

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

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community does lowering your prolactin levels regrow hair?

in Research/Science 10 upvotes 1 year ago

The potential of lowering prolactin levels to regrow hair, with a reference to Bayer's drug HMI 115 which has been indicated as having this effect. Treatments mentioned include Minoxidil and Finasteride, as well as RU58841.

community Does lowering serum prolactin lower prolactin in the scalp?

in Research/Science 13 upvotes 10 months ago

The conversation discusses whether not masturbating (semen retention) affects hair loss, with opinions varying but generally dismissing the idea. Some participants mention using hair loss treatments like Minoxidil, Finasteride, and RU58841, but the effectiveness and relation to prolactin levels in the scalp are debated.

community Why HMI115 should work if it doesn’t affect dht?

in Research/Science 16 upvotes 1 year ago

Hair growth can be induced without stopping DHT, as seen with Minoxidil. HMI115 may work by promoting follicle growth, not targeting the root cause of hair loss (DHT).

community Two Great Articles on NCBI That Summarize What We Actually Know About Finasteride Side Effects

in Finasteride 80 upvotes 5 years ago

The side effects of taking finasteride as a treatment for hair loss, with particular focus on its sexual and psychiatric side effects; research has indicated that there are high and low outliers in terms of prevalence of sexual side effects, but it is usually between 3-5%, while evidence of lasting sexual side effects comes from lower quality sources.

community 5ARI (dutasteride) Associated with Adverse Metabolic Effects

23 upvotes 6 years ago

Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.

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