Endocannabinoids Limit Excessive Mast Cell Maturation And Activation In Human Skin

    January 2012 in “ Journal of Allergy and Clinical Immunology ”
    Koji Sugawara, Tamás Bı́ró, Daisuke Tsuruta … Ralf Paus
    Studysummary This study found that activation of cannabinoid 1 receptors in human scalp hair follicles may limit excessive mast cell activation and maturation, suggesting a potential therapeutic strategy for managing MC-dependent skin diseases.
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    Research cited in this study 8

    1. Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    2. Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ The FASEB Journal · 2010
    3. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    4. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    5. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    6. Neuroimmunology of Stress: Skin Takes Center Stage Journal of Investigative Dermatology · 2006
    7. Mast Cell Deficient and Neurokinin-1 Receptor Knockout Mice Are Protected from Stress-Induced Hair Growth Inhibition Journal of Molecular Medicine · 2005
    8. The Biology of Hair Follicles The New England Journal of Medicine · 1999