Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases

The document discusses the potential of cannabinoid compounds, particularly CBD and THC, in treating non-cancer skin diseases. The endocannabinoid system, which includes receptors and enzymes, plays a role in various skin functions and diseases. Cannabinoids have shown promise in treating conditions such as androgenetic alopecia, dermatitis, dermatomyositis, eczema, and psoriasis, among others. They can influence wound healing, scar formation, skin inflammation, and hair growth. For instance, activation of the CB1 receptor can promote the proliferation of hair follicle epithelial progenitor cells, suggesting potential treatments for alopecia. However, more research is needed to understand the exact mechanisms and potential side effects. The document also highlights the need for future clinical trials to explore combining cannabinoids with other drugs for enhanced therapeutic effects.