TLDR Activating TRPV3 stops human hair growth.
The study concluded that activation of the Transient Receptor Potential Vanilloid-3 (TRPV3) ion channel inhibited human hair growth by suppressing cell proliferation and inducing apoptosis in outer root sheath (ORS) keratinocytes. Using human hair follicles (n=18-24 per group) and various assays, the researchers demonstrated that TRPV3 activators like eugenol and 2-APB increased calcium influx, leading to these effects. The findings suggested that TRPV3 could be a promising target for developing treatments for hair growth disorders, with potential applications for both unwanted hair growth and hair loss conditions like alopecia.
64 citations,
January 2010 in “The FASEB Journal” Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.
59 citations,
November 2007 in “Biochemical and Biophysical Research Communications” The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.
293 citations,
January 2006 in “Trends in Immunology” Stress can worsen skin conditions and stop hair growth by affecting the body's stress response system.
174 citations,
April 2005 in “The American journal of pathology (Print)” Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.
1113 citations,
August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.