Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth

May 2011 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

István Borbíró, Erika Lorenzetto, Balázs István Tóth, Gabriella Czifra, Attila Oláh, Attila Gábor Szöllősi, Norbert Szentandrássy, Péter P. Nánási, Zoltán Péter, Ralf Paus, László Kovács, Tamás Bı́ró

Transient Receptor Potential Vanilloid-3 TRPV3 eugenol 2-APB outer root sheath keratinocytes calcium influx apoptosis alopecia outer root sheath cells calcium increase cell death hair loss

TLDR Activating TRPV3 stops human hair growth.

The study concluded that activation of the Transient Receptor Potential Vanilloid-3 (TRPV3) ion channel inhibited human hair growth by suppressing cell proliferation and inducing apoptosis in outer root sheath (ORS) keratinocytes. Using human hair follicles (n=18-24 per group) and various assays, the researchers demonstrated that TRPV3 activators like eugenol and 2-APB increased calcium influx, leading to these effects. The findings suggested that TRPV3 could be a promising target for developing treatments for hair growth disorders, with potential applications for both unwanted hair growth and hair loss conditions like alopecia.

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