Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth

    May 2011 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    István Borbíró, Erika Lorenzetto, Balázs István Tóth, Gabriella Czifra, Attila Oláh, Attila Gábor Szöllősi, Norbert Szentandrássy, Péter P. Nánási, Zoltán Péter, Ralf Paus, László Kovács, Tamás Bı́ró
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    TLDR Activating TRPV3 stops human hair growth.
    The study concluded that activation of the Transient Receptor Potential Vanilloid-3 (TRPV3) ion channel inhibited human hair growth by suppressing cell proliferation and inducing apoptosis in outer root sheath (ORS) keratinocytes. Using human hair follicles (n=18-24 per group) and various assays, the researchers demonstrated that TRPV3 activators like eugenol and 2-APB increased calcium influx, leading to these effects. The findings suggested that TRPV3 could be a promising target for developing treatments for hair growth disorders, with potential applications for both unwanted hair growth and hair loss conditions like alopecia.
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