Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes

    September 2017 in “ Journal of Investigative Dermatology ”
    Attila Gábor Szöllősi, Nikolett Vasas, Ágnes Angyal, Kornél Kistamás, Péter P. Nánási, Johanna Mihály, Gabriella Béke, Erika Herczeg-Lisztes, Andrea Szegedi, Naoki Kawada, Takashi Yanagida, Takahiro Mori, Lajos Kemény, Tamás Bı́ró
    TLDR TRPV3 in skin cells causes inflammation and cell death.
    The study demonstrated that TRPV3, a transient receptor potential ion channel, was expressed in human skin and cultured epidermal keratinocytes. Activation of TRPV3 functioned as a Ca2+-permeable ion channel, which suppressed keratinocyte proliferation and induced cell death. Additionally, TRPV3 stimulation triggered a strong proinflammatory response via the NF-κB pathway. These findings suggested that TRPV3 played a significant role in cutaneous inflammatory processes and could be linked to conditions such as Olmsted syndrome, characterized by symptoms like alopecia and hyperkeratosis.
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