Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes

    February 2018 in “ Journal of Investigative Dermatology ”
    Attila Gábor Szöllősi, Nikolett Vasas, Ágnes Angyal, Kornél Kistamás, Péter P. Nánási, Johanna Mihály, Gabriella Béke, Erika Herczeg-Lisztes, Andrea Szegedi, Naoki Kawada, Takashi Yanagida, Takahiro Mori, Lajos Kemény, Tamás Bı́ró
    TLDR TRPV3 in skin cells causes inflammation and cell death.
    In this study, researchers identified the expression of TRPV3 on human skin and cultured epidermal keratinocytes, finding that TRPV3 functions as a Ca2+-permeable ion channel that suppresses keratinocyte proliferation and induces cell death. Additionally, TRPV3 stimulation triggered a strong proinflammatory response via the NF-κB pathway, indicating that TRPV3 plays a significant role in cutaneous inflammatory processes. This research provided new insights into the cellular-level functionality of TRPV3, particularly its involvement in skin inflammation and conditions such as Olmsted syndrome, which is associated with symptoms like alopecia.
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