Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes

    September 2017 in “ Journal of Investigative Dermatology ”
    Attila Gábor Szöllősi, Nikolett Vasas, Ágnes Angyal, Kornél Kistamás, Péter P. Nánási, Johanna Mihály, Gabriella Béke, Erika Herczeg-Lisztes, Andrea Szegedi, Naoki Kawada, Takashi Yanagida, Takahiro Mori, Lajos Kemény, Tamás Bı́ró
    Studysummary This study found that TRPV3 ion channels on human epidermal keratinocytes suppress cell proliferation, induce cell death, and trigger a proinflammatory response, suggesting a role in cutaneous inflammatory processes. Our plain-language summary of this paper — not a Tressless recommendation.
    The study demonstrated that TRPV3, a transient receptor potential ion channel, was expressed in human skin and cultured epidermal keratinocytes. Activation of TRPV3 functioned as a Ca2+-permeable ion channel, which suppressed keratinocyte proliferation and induced cell death. Additionally, TRPV3 stimulation triggered a strong proinflammatory response via the NF-κB pathway. These findings suggested that TRPV3 played a significant role in cutaneous inflammatory processes and could be linked to conditions such as Olmsted syndrome, characterized by symptoms like alopecia and hyperkeratosis.
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