Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes

September 2017 in “ Journal of Investigative Dermatology ”

Attila Gábor Szöllősi, Nikolett Vasas, Ágnes Angyal, Kornél Kistamás, Péter P. Nánási, Johanna Mihály, Gabriella Béke, Erika Herczeg-Lisztes, Andrea Szegedi, Naoki Kawada, Takashi Yanagida, Takahiro Mori, Lajos Kemény, Tamás Bı́ró

TRPV3 human epidermal keratinocytes Ca2+-permeable ion channel keratinocyte proliferation cell death proinflammatory response NF-κB pathway cutaneous inflammatory processes Olmsted syndrome alopecia calcium-permeable ion channel skin cells inflammation hair loss

TLDR TRPV3 in skin cells causes inflammation and cell death.

The study demonstrated that TRPV3, a transient receptor potential ion channel, was expressed in human skin and cultured epidermal keratinocytes. Activation of TRPV3 functioned as a Ca2+-permeable ion channel, which suppressed keratinocyte proliferation and induced cell death. Additionally, TRPV3 stimulation triggered a strong proinflammatory response via the NF-κB pathway. These findings suggested that TRPV3 played a significant role in cutaneous inflammatory processes and could be linked to conditions such as Olmsted syndrome, characterized by symptoms like alopecia and hyperkeratosis.

View this study on jidonline.org →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth

105 citations, May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

Activating TRPV3 stops human hair growth.

research Influence of TRPV3 Mutation on Hair Growth Cycle in Mice

59 citations, September 2007 in “Biochemical and Biophysical Research Communications”

The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.

research A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control

174 citations, April 2005 in “The American journal of pathology (Print)”

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Related Community Posts Join

3 / 3 results

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 1 upvotes 2 weeks ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 411 upvotes 2 weeks ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Progress pictures. 2 months on Fin, 4 on Min.

in Progress Pictures 191 upvotes 2 months ago

The user experienced significant hair regrowth after using Finasteride for 2 months and Minoxidil for 4 months, along with a derma roller. They reported no side effects from the treatments and noted that Finasteride seemed to contribute most to the progress.

Related Research

1 / 1 results

research Development of Pigmented Reconstructed Human Epidermis Model Containing Human Melanoblasts from Keratinocyte Culture

April 2019 in “Journal of Investigative Dermatology”

The created skin model with melanoblasts improves the study of skin color and offers an alternative to animal testing.